2021 Training Courses and Events

BOOK WITH CONFIDENCE GUARANTEE*

2021 TRAINING COURSES &EVENTS

BOOK WITH CONFIDENCE GUARANTEE*

ONLINE Events

FACE TO FACE Events

www.scientificupdate.com

info@scientificupdate.com

“GREATSCIENCE, EXCELLENTTUTORS ANDLOTSOFFUN.”

2020DELEGATE

CONTENTS

Various discounts available! See the website for details

Dates for your diary

MODERN SYNTHETIC ORGANIC REACTIONS

AN INTRODUCTION TO CHEMICAL ENGINEERING SCIENCE

MOLECULE TO MEDICINE

APPLIED MIXING TECHNOLOGY FOR PROCESS DEVELOPMENT: SCALING DOWN TO SCALE UP

ORGANOCATALYSIS SHORT COURSE

BIOCATALYSIS – SOLVING SCALE-UP ISSUES WITH BIOCATALYSED REACTIONS

PHOTOREDOX CATALYSIS IN ORGANIC SYNTHESIS

BIOCATALYSIS AS A TOOL FOR THE SYNTHETIC CHEMIST

PHYSICAL ORGANIC CHEMISTRY CONCEPTS FOR PROCESS DEVELOPMENT

CHEMICAL DEVELOPMENT & SCALE-UP IN THE FINE CHEMICAL & PHARMACEUTICAL INDUSTRIES

PRACTICAL MANAGEMENT OF IMPURITIES AND DEVELOPMENT OF EFFECTIVE AND COMPREHENSIVE CONTROL STRATEGIES

CHEMICAL ENGINEERING: WHAT SCIENTISTS AND OTHER ENGINEERS NEED TO KNOW

QUALITY BY DESIGN IN PHARMACEUTICAL DEVELOPMENT

DESIGN, DEVELOPMENT & SCALE-UP OF SAFE CHEMICAL PROCESSES & OPERATIONS – DEKRA

SAFETY & SELECTIVITY IN THE SCALE UP OF CHEMICAL REACTIONS

DESIGN OF EXPERIMENTS FOR CHEMISTS AND ENGINEERS (DOE)

SCALE-UP: WHAT GOES WRONG? SHORT COURSE

FILTRATION AND DRYING

SECRETS OF BATCH PROCESS SCALE-UP

FLOW CHEMISTRY

SYNTHETIC ORGANIC ELECTROCHEMISTRY SHORT COURSE

GRIGNARD CHEMISTRY SHORT COURSE

UNDERSTANDING POLYMORPHISM & CRYSTALLISATION ISSUES IN THE PHARMACEUTICAL INDUSTRY

HETEROGENEOUS CATALYTIC HYDROGENATION

WORK UP AND PRODUCT ISOLATION

KINETIC MODELLING: WHAT’S IN IT FOR ME AND HOW TO GET STARTED

Conferences

MEDICINAL CHEMISTRY

Delivering conferences and training courses for industrial chemists and chemical engineers in chemical development, scale-up and many other specialist topics in organic chemistry.

IT’SEASY TO REGISTER ONLINE

Last year alone: OUR STRENGTH IN NUMBERS 100%*

1230

15,000 of the top 20 pharma companies sent their employees to our events webinar attendees worldwide

people attended our events in 2020

“As a relatively young PhD chemist joining industry only a month prior to the course, this was a perfect introduction to the scope and variety of scale- up problems that I would never have previously encountered.”

“The OPRD has become one of my favourite conferences, and the virtual version this year has been great. Congratulations to Scientific Update for their great work!” OPRD VIRTUAL CONFERENCE ATTENDEE, DECEMBER 2020

SECRETS OF BATCH VIRTUAL COURSE.

15

50%

29 free webinars delivered in 2020

in-house training courses delivered

of the Top Pharma companies and Top Agrichemical Companies choose to use us for In House Courses

*Top 20 Pharma companies as defined on PharmExec.com

www.scientificupdate.com

info@scientificupdate.com

DATES

DATES FOR YOUR DIARY 2021 ALL COURSES ARE ONLINE UNLESS THEY HAVE THIS SYMBOL:

WHAT WE OFFER CONFERENCES High quality conferences each featuring over 16 industry experts and invaluable networking opportunities CONSULTANCY Solving problems and managing projects in Process Research and Development COURSES Over 40 training courses in 18 different subjects, hosting over 1000 attendees annually from 91 countries E-NEWSLETTER Free e-Newsletter packed with updates within the industry and read by over 3000 industry professionals INHOUSE TRAINING Bespoke In House training delivered on any of our courses direct within your own premises FREEWEBINARS FREE online training to allow you to keep your skills up to date For more information on any of our services please visit our website: www.scientificupdate.com

SECRETS OF BATCH PROCESS SCALE-UP 19 - 23 April CHEMICAL DEVELOPMENT

GRIGNARD CHEMISTRY SHORT COURSE 25 - 26 May

FEBRUARY SYNTHETIC ORGANIC ELECTROCHEMISTRY SHORT COURSE 22 - 24 February SCALE-UP: WHAT GOES WRONG? SHORT COURSE 23 - 24 February ORGANOCATALYSIS SHORT COURSE 24 - 25 February MARCH CHEMICAL DEVELOPMENT & SCALE-UP IN THE FINE CHEMICAL & PHARMACEUTICAL INDUSTRIES 3, 4, 5, 8, 9, 10 March SECRETS OF BATCH PROCESS SCALE-UP 8 - 12 March PRACTICAL MANAGEMENT OF IMPURITIES AND DEVELOPMENT OF EFFECTIVE AND COMPREHENSIVE CONTROL STRATEGIES 16,17 and 23-24 March DESIGN, DEVELOPMENT AND SCALE-UP OF SAFE CHEMICAL PROCESSES AND OPERATIONS 15 - 19 March KINETICMODELLING: WHAT’S IN IT FORME AND HOWTOGET STARTED 23 - 25 March WORK UP AND PRODUCT ISOLATION 30 - 31 March APRIL BIOCATALYSIS – SOLVING SCALE-UP ISSUES WITH BIOCATALYSED REACTIONS 7 - 8 April FLOWCHEMISTRY 9, 12, 13, 14 April

SOLVENTS AND SOLVENT SELECTION IN CHEMICAL MANUFACTURING 26 - 28 May PHOTOREDOX CATALYSIS IN ORGANIC SYNTHESIS 27 - 28 May JUNE CATALYSIS IN THE FINE CHEMICAL AND PHARMACEUTICAL INDUSTRIES CONFERENCE 2 - 3 June QUALITY BY DESIGN IN PHARMACEUTICAL DEVELOPMENT 14 - 18 June CHEMICAL DEVELOPMENT INDUSTRIES 15 - 17 June Dublin, Ireland FITRATION AND DRYING 15 - 17 June MEDICINAL CHEMISTRY 22 - 24 June Hamburg, Germany Polymorphism& Crystallisation Conference 28 - 29 June PROCESS ANALYTICAL TECHNOLOGY CONFERENCE 30 June & SCALE-UP IN THE FINE CHEMICAL & PHARMACEUTICAL

& SCALE-UP IN THE FINE CHEMICAL & PHARMACEUTICAL INDUSTRIES 19 - 23 & 26 April

AN INTRODUCTION TO CHEMICAL ENGINEERING SCIENCE 26 - 29 April DESIGNOF EXPERIMENTS FOR CHEMISTS AND ENGINEERS 27 - 30 April MAY FLOWCHEMISTRY AND CONTINUOUS PROCESSING CONFERENCE 10 - 12 May FLUID TRANSFER AND LIQUIDMIXING – MODULE 1 10 May MASS TRANSFER APPLICATIONS – MODULE 2 11 May HEAT TRANSFER EQUIPMENT AND DRYING – MODULE 3 12 May SAFETY & SELECTIVITY IN THE SCALE-UP OF CHEMICAL REACTIONS 12 - 13 May APPLIEDMIXING TECHNOLOGY FOR PROCESS DEVELOPMENT: SCALING DOWN TO SCALE UP 17 - 20 May MOLECULE TOMEDICINE 18 - 20 May Madrid, Spain BIOCATALYSIS – AS A TOOL FOR THE SYNTHETIC CHEMIST 17 - 20 May

Various discounts available! See the website for details

BOOK NOW!

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION.

BOOK WITH CONFIDENCE!

ANINTRODUCTIONTO CHEMICALENGINEERING SCIENCE

ONLINE Events

An Online course delivered by Britest Ltd in conjunction with Scientific Update R&D scientists are often at a disadvantage when working in process research and development because of their lack of knowledge about the basic principles of chemical engineering, and the impact COURSE OUTLINE

EXTRA SESSIONS

Module 1: Fluid Transfer and Mixing Monday May 10 th 2.00 – 5.00pm UK Module 2: Mass Transfer Applications Tuesday May 11 th 2.00 – 5.00pm UK Module 3: Heat Transfer Equipment and Drying Wednesday May 12 th 2.00 – 5.00pm UK You can add these modules to your booking of this course, or you can also book onto them individually.

information and data that chemical engineers require for design, scale-up and process troubleshooting. Chemical engineering without mathematics is impossible, but this course presents only relevant mathematics at a level that should not trouble anyone with a numerate scientific degree. Other disciplines do not need to know how to design plants or equipment and this course does not attempt to teach this. The course focuses on understanding chemical engineering principles to promote clear communication between disciplines, facilitating information and knowledge transfer.

of decisions regarding process yield and selectivity on up- and downstream operations. Other

branches of engineering face a similar disadvantage when considering the whole process. This course has been developed, and is presented, by chemical engineers and chemists who specialise in facilitating knowledge transfer and understanding between different scientific and engineering disciplines working at the R&D-manufacturing interface. As a result, it does not dwell on the derivation of mathematical formulae or equations used in chemical engineering design, but instead focuses on what other disciplines need to know about the

WHO SHOULD ATTEND?

This course would be useful to any Scientists, Technologists or Engineers from other branches of engineering who are involved in process research and development, scale-up or manufacturing.

COURSE TUTOR

ONLINE DELEGATE 2020 “Really well organised and useful topics”.

Mr Robert Peeling

WHEN &WHERE

Dates 2021

Price

Location

26 - 29 April 2.00-5.00pm (UK)

£795.00 + VAT

Online

10 – 12 May

£195.00 + VAT each session*

Online

Fee includes attendance at all the live, interactive sessions (except for the extra modules) *if you book the course and all three modules you get one module FREE

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

APPLIEDMIXINGTECHNOLOGY FORPROCESSDEVELOPMENT: SCALINGDOWNTOSCALEUP

NEW COURSE

ONLINE Events

Use of the proper mixing technology is often essential for successful process results. This online course considers how we can choose appropriate mixing conditions for laboratory, pilot, and commercial scale units to ensure technical success. The course begins by rooting us in some essential basics of mixing technology. With those fundamentals, we then progress through different mixing applications in increasing levels of complexity: single-phase (blending and heat transfer), multiple phase (solid-liquid, COURSE OUTLINE

WHO SHOULD ATTEND?

Scientists and engineers in the chemical and pharmaceutical industries who are involved in process development, scale-up/scale- down, troubleshooting, and process optimization.

immiscible liquid, gas-liquid, and 3-phase), and mixing in competitive rate processes (reactions and crystallizations). Throughout, we look at scale-up and scale-down by using examples from industrial processes which have a variety of mixing requirements. We will discuss how to design and execute practical experiments at the small scale which can identify mixing sensitivities in a process that could be an issue on scale-up. Though primarily focusing on operations in stirred tanks, we will also discuss mixing applications in flow systems like static mixers.

COURSE TUTOR

Aaron Sarafinas

WHEN &WHERE

Dates 2021

Price

Location

17 - 20 May 2.00-5.00pm (UK)

£595.00 + VAT

Online

FEE INCLUDES: • Live interactive training sessions based over 4 afternoons (UK time) using an online webinar platform • E Reader version of the manual (professionally printed versions of the manual are available but at an additional cost to cover postage) • Course certificate

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

BIOCATALYSIS–SOLVING SCALE-UP ISSUESWITH BIOCATALYSEDREACTIONS

ONLINE Events

COURSE OUTLINE Many forays by organic chemists into using biocatalysis in chemical synthesis stall at the initial scale- up stage. Screening and small scale (gram) reactions progress as planned, but when scaled -up, reactions stall, take more enzyme than expected, work-ups end up with emulsion issues etc. This course will look at some of the techniques and technologies ( tricks of the trade) that can help derisk scaling up biocatalysed reactions .A further barrier to the adoption of more biocatalytic reactions are production / EHS scientists who are unsure how to handle enzymes in the plant/pilot plant. the course will also look at good sources of information/data to facilitate the use of enzymes at scale.

HIGHLIGHTS

• Enzyme supply chain: Storage, stability etc • Techno-economic analysis – will the transformation ever hit the required targets? • Different types of strains used and its safety impactions. • Using GMO’s and GMO derived materials • Handling concerns related to enzyme -SHE/EHS issues., Safety issues in scaling up biocatalytic reactions • Pros and cons of different enzyme formulations • Enzyme stability: General to pH, co-solvent, temperature as linked to process design and development • Enzyme analysis / characterisation – needed to assess purity in order to calculate activity and so expected long term cost, spec setting / quality control (ensure plant samples match lab samples and measure variation over time). • Scale-up – reactor options – various reactor types, std batch, continuous, membrane separated, continuous liquid extraction, etc • Product isolation from complex mix . Enzyme removal/ downstream

processing– to be intelligent in terms of what can and can’t be removed vs effects on process including downstream chemistry. • Use of immobilised enzymes/ Recycling of immobilised enzymes

VIRTUAL DELEGATE 2020 “I really enjoyed the virtual Short Course and it was very good incl. the thorough collection of examples etc. Looking forward to the next ones!”

COURSE TUTOR

Scientists working in medicinal/process chemistry and are interested in moving frommg/screening scale to 100’ s grams-multi kg scale. WHO SHOULD ATTEND?

Dr Andrew Wells

WHEN &WHERE

Dates 2021

Price

Location

7 - 8 April 1.30 - 4.00pm (UK)

£295.00 + VAT Online

Please note: this course assumes some prior existing knowledge of biocatalysis / biotransformations as applied to synthetic organic chemistry, either in theory or some prior practical use at screening/ small scale laboratory experimentation, an appreciation of different enzyme classes etc.

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

BIOCATALYSISASATOOLFORTHE SYNTHETICCHEMIST

ONLINE Events

COURSE OUTLINE The aim of the course is to give organic chemists an understanding and an overview of the subject of biotransformations. Attendees will learn about the main classes of enzymes and the transformations these enzymes carry out. Each transformation type will be illustrated with examples and case studies and the course will also include problem sessions where attendees will work on real examples

• Any Organic Chemist involved in synthesis, particularly those involved in designing novel, green synthetic routes. • Chemists who want to learn how biocatalysis can help them. • Those involved in the scale-up of biocatalytic reactions. WHO SHOULD ATTEND?

the sort of equipment and resources required for research and scaling up biocatalytic reactions. Several industrial examples of biocatalysis will be discussed. The Course will conclude with a comparison of biocatalysis and chemocatalysis.

applying biotransformations to organic synthesis. Recent developments in the field will be covered as well as an overview of

ONLINE GIVAUDAN SCHWEIZ AG DELEGATE “Very well presented topics regarding biocatalysis. It was exciting, and I definitively learned some new aspects of biocatalysis.”

ONLINE GIVAUDAN DELEGATE “A broad type of enzymatic reaction was described. Tips and hints are very useful.”

COURSE TUTORS

Dr Will Watson

Dr Andrew Wells

WHEN &WHERE

Dates 2021

Price

Location

17-20 May 2.00-5.00pm (UK)

£1,340 + VAT Online

FEE INCLUDES: • Live interactive training sessions based over 4 afternoons (UK time) using an online webinar platform • E Reader version of the manual (professionally printed versions of the manual are available but at an additional cost to cover postage) • Course certificate

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

CHEMICALDEVELOPMENT& SCALE-UP INTHEFINECHEMICAL &PHARMACEUTICAL INDUSTRIES

ONLINE AND FACE TO FACE

Chemical process development is generally not taught as part of degree courses in higher education; the conversion of a synthetic route used for making milligram or gram quantities of a chemical into a process for manufacturing multi- kilogram and tonne quantities is typically learnt “on the job” by chemists in industry. For many years, little chemical development work was published in the literature, until the establishment of the Organic Process R & D journal by Dr Trevor Laird (Founder of Scientific Update). Even now, “tricks of the trade” are handed down within individual company organisations, and it can be difficult to gain an awareness of what is involved in chemical development, and of the skills and techniques required to efficiently scale up chemical processes. COURSE OUTLINE

WHO SHOULD ATTEND?

This three-day course, delivered over 6 half days for the online courses, is written and presented by highly experienced process chemists from the pharmaceutical and fine chemical industries, provides a comprehensive overview of this fascinating and important element of the chemical industry. A logical investigative approach to all aspects of chemical development is described, with an abundance of case studies from literature, conferences and private communications. The multi-disciplinary nature of chemical development is emphasised, from the initial interaction with laboratory research scientists to the vital partnership with chemical engineers in the pilot plant and in the production environment.

• Young Chemists who have just started work in industry as development chemists • Organic Chemists/Medicinal Chemists in Research and Development who would like to gain an appreciation of development and scale up and who are perhaps contemplating moving into chemical development. • Development and Production Chemists in industry who would like to improve their efficiency and gain an insight into alternative approaches to chemical development. • Chemical Engineers who wish to understand a chemist’s approach to chemical development of batch processes. (Engineers would, however, need a good grounding in organic chemistry) • Students who are about to enter the industry and can obtain company sponsorship. • Experienced Chemists looking to refresh and/ or augment their knowledge of chemical development • Analytical Chemists who wish to gain a broader appreciation of process chemistry • Managers who might benefit from a comprehensive and up to date overview of chemical development

COURSE TUTORS

Dr Will Watson

Dr John Studley

Dr Jonathan Moseley

Dates 2021

Price

Location

3 - 10 March 4.00-7.00pm (UK)

£1,699.00 + VAT Online

19 – 23 & 26 April 8.30 - 11.30am (UK)

£1,699.00 + VAT Online

BOOK WITH CONFIDENCE!

15 - 17 June

€2,199.00

Dublin, Ireland

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION.

25 – 27 October

$2,499.00

San Francisco, USA

10 – 12 November

€2,199.00

Nice, France

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

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CHEMICALENGINEERING:WHAT SCIENTISTSANDOTHERENGINEERS NEEDTOKNOW

FACE TO FACE Events

A 3-day course delivered by Britest Ltd in conjunction with Scientific Update R&D scientists are often at a disadvantage when working in process research and development because of their lack of knowledge about the basic principles of chemical engineering, and the impact of decisions regarding process yield and selectivity on up- and downstream operations. Other branches of engineering face a similar disadvantage when considering the whole process. This course has been developed, and is presented, by chemical engineers and chemists who specialise in facilitating knowledge transfer and understanding between different scientific and engineering disciplines working at the R&D-manufacturing interface. As a result, it does not dwell on the COURSE OUTLINE

This course would be useful to any scientists and technologists, or engineers from other branches of engineering, who are involved in process research & development, scale-up, or manufacturing. The course will help enable better technology transfer and communication with your chemical and process engineers. WHO SHOULD ATTEND?

derivation of mathematical formulae or equations used in chemical engineering design, but instead focuses on what other disciplines need to know about the information and data that chemical engineers require for design, scale-up and process troubleshooting. Chemical engineering without mathematics is impossible, but this course presents only relevant mathematics at a level that should not trouble anyone with a numerate scientific degree. Other disciplines do not need to know how to design plants or equipment and this course does not attempt to teach this. The course focuses on understanding chemical engineering principles to promote clear communication between disciplines, facilitating information and knowledge transfer.

JOHNSON MATTHEY DELEGATE 2019

“Rob and Charlie were great, their explanations are clear and they are always open to discuss topics, which I found very useful. The textbook is useful and clear. I have enjoyed the course. Thank you!”

COURSE TUTORS

Delivered in conjunction with Britest Ltd

Mr Robert Feeling

WHEN &WHERE

BOOK WITH CONFIDENCE!

Dates 2021

Price

Location

2 – 4 November

€1,799.00

Basel, Switzerland

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION. ONLINE A VERSION OF THIS COURSE IS ALSO AVAILABLE ONLINE - SEE PAGE 4

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

DESIGN,DEVELOPMENT& SCALE-UPOFSAFECHEMICAL PROCESSES&OPERATIONS– DEKRA

ONLINE Events

Developing safe processes is of paramount importance to any chemical company. Exothermic chemical reactions in batch and semi- batch processes can result in serious injury to people and plant if they get out of control. Results of thermal runaways include violent loss of containment, possibly explosion and the release of flammable or toxic materials to the environment. Employers are bound by Health & Safety legislation to ensure the safety of their employees and those outside their employment who might be affected by their activities. Chemical manufacturers must therefore be aware of all potential dangers in their processes and take steps to eliminate them. The best approach is to design safety into the process from the start. COURSE OUTLINE

engineers regarding hazard issues. Utilising the expertise of the chemists and chemical engineers at DEKRA and Scientific Update, it will consider hazard control of new chemical processes throughout their development cycle: from early development through to full-scale production.

Often, the first sign of loss of control over a reaction is a reduction in yield or in the quality of the product. Thus safety, quality and profitability are all interlinked. The course focuses on plant protection and safety systems designed to prevent or protect against runaway reaction scenarios. This includes extensive discussion and workshops on process control strategies and emergency relief system design for two-phase relief using DIERS methodology. The course makes extensive use of case studies to help embed principles and key learning points such that attendees leave with tools they can immediately deploy. This seminar is designed to enhance the awareness of chemists and

WHO SHOULD ATTEND?

Process R&D Chemists, Production Chemists, Chemical Engineers and anyone whose responsibilities include safety or risk assessment of chemical processes or building safety into chemical process scale-up.

Dr Stephen Rowe

Dr Keith Middle

Dr Will Watson

WHEN &WHERE

Dates 2021

Price

Location

15 - 19 March 2.00 - 5.30pm (UK) Each Day

£695.00 VAT

Online

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

DESIGNOFEXPERIMENTSFOR CHEMISTSANDENGINEERS

ONLINE Events ONLINE AND FACE TO FACE

Industrial Scientists can no longer afford to experiment in a trial-and- error manner, changing one factor at a time. A far more effective method is to apply a systematic approach to experimentation that considers all factors simultaneously. This approach is called Design of Experiments (DoE) and many scientists use it as an efficient way to solve serious problems afflicting their projects. DoE provides information about the interaction of factors and the way the total system works, something not obtainable through traditional testing methods. DoE also shows how interconnected factors respond over a wide range of values, without requiring the testing of all possible values directly. DoE is a fundamental aspect of Quality by Design. COURSE OUTLINE

• Lab scientists • Process development scientists • Industrial researchers • Project managers WHO SHOULD ATTEND?

This now four session course written and presented by Dr Paul Murray a Process Chemist with extensive experience of applying DoE across a wide range of chemical reactions from reaction screening and new route development through to reaction optimisation. The Course will empower Scientists to implement DoE in their work to more efficiently improve their processes.

SOCIÉTÉ SUISSE DES EXPLOSIFS DELEGATE “Thank you very much to Paul and Laura! I have learned a lot about the theory and application of DoE, well- equilibrated course. I’ll definitely recommend it!”

COURSE TUTOR

Dr Paul Murray

WHEN &WHERE

BOOK WITH CONFIDENCE!

Dates 2021

Price

Location

27 - 30 April 1.30-5.30pm (UK) Each Day

£1,340.00 + VAT

Online

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION.

15 – 16 September

€1,699.00

Cologne, Germany

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

FILTRATIONANDDRYING

ONLINE Events

New products can only be brought to market successfully with a viable whole process behind them. Your (bio-)synthesis and work- up might well be exciting and innovative but unless the isolated product can be handled and suitably packaged then commercial success is unlikely. Chemists, biologists, and engineers regularly interact and collaborate in process development projects. To do so within an effective team each must understand the needs and objectives of the other disciplines. This course gives scientists and engineers from other disciplines an introduction into the chemical engineering involved in the isolation and drying of products following chemical or biochemical synthesis and work-up. COURSE OUTLINE

WHO SHOULD ATTEND?

The aim is to equip participants with sufficient understanding of the underlying principles of filtration and drying to successfully engage in multi- disciplinary discussions within their project teams and identify the data requirements to enable successful process scale-up.

Scientists and process technologists involved in chemical or biochemical process scale-up bringing new products from synthesis to commercialisation.

Delivered in conjunction with Britest Ltd

ONLINE LEO PHARMA DELEGATE

“This course provided a very good introduction to different techniques. It gave some good suggestions as to what aspects to consider and test when choosing a technique, or wanting to understand your equipment better.”

COURSE TUTOR

Mr Robert Peeling

WHEN &WHERE

Dates 2021

Price

Location

15 - 17 June 2.00-5.00pm (UK) Each Day

£595.00 + VAT Online

FEE INCLUDES: • Live interactive training sessions based over 4 afternoons (UK time) using an online webinar platform • E Reader version of the manual (professionally printed versions of the manual are available but at an additional cost to cover postage) • Course certificate

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

FLOWCHEMISTRY

ONLINE AND FACE TO FACE

Flow chemistry has been used in petrochemical and bulk chemical production for over 100 years, but has only seen significant interest in the pharmaceutical and fine chemical industries in the past 10 years. This course aims to give an introduction to this exciting and revolutionary field, to familiarise attendees with the current state of the art. A wide range of highlights from the flow chemistry literature will be discussed, from both academia and industry, with a focus on translating conventional reactions to flow COURSE OUTLINE

• Industrial chemists • Chemical engineers in process chemists in chemical development and scale-up WHO SHOULD ATTEND?

processes. Attendees will become familiar with a number of distinct types of flow reactors, allowing the correct reactor to be chosen to suit the required chemistry. Emphasis will also be placed on the inline and online monitoring of flow reactions, along with the hazards and pitfalls associated with scaling up flow reactions. There will be a Face to Face version of this course ran in November 2021 where we will also be running the additional Masterclass at the University of Graz.

DEVCHEM PTY LTD “An excellent course summarising the state of the art in flow chemistry. Highly recommended.”

COURSE TUTORS

Professor C Oliver Kappe

Dr Will Watson

Dr John Studley

WHEN &WHERE

BOOK WITH CONFIDENCE!

Dates 2021

Price

Location

9,12,13,14 April 2.00-5.00pm (UK) Each Day

£1,340.00 + VAT

Online

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION.

3 - 5 November

€1,899.00 Masterclass €700.00

Graz, Austria

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

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GRIGNARDCHEMISTRY SHORTCOURSE

ONLINE Events

COURSE OUTLINE

WHO SHOULD ATTEND?

This online course will be of interest to anyone involved in synthetic organic chemistry, since every chemist will run at least one Grignard reaction in their life.

This onine short course that will look at synthetic and scale up aspects of making and using Grignard reagents. The course will be in two sections of 60-90 minutes held over two consecutive days as follow:

Session 2: Recent examples of using Grignard reagents, and making Grignard reagents in continuous flow mode. This presentation will cover recent developments in the use of Grignard reagents such as Kumada and Negishi couplings along with the preparation and use of Grignard reagents in flow with particular emphasis on the scale up of flow processes for the preparation of Grignard reagents via industrial case studies. • Recent examples of using Grignard reagents • Making Grignard reagents in continuous flow mode.

Session 1: Making Grignard reagents and safety aspects of making and handling Grignard reagents.

This presentation will cover the main ways for preparing organomagnesium compounds, and consider their relative reactivity and stability once prepared. In addition the safety issues associated with making organomagnesium compounds will be discussed. The presentation will use real life case studies to illustrate the various aspects of preparation, stability and safety. • Introduction • Making Grignard reagents on scale • Safety issues

COURSE TUTOR

Dr Will Watson

WHEN &WHERE

Dates 2021

Price

Location

25 - 26 May

£255.00 + VAT

Online

FEE INCLUDES: • Live interactive training sessions based over 4 afternoons (UK time) using an online webinar platform • E Reader version of the manual (professionally printed versions of the manual are available but at an additional cost to cover postage) • Course certificate

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

HETEROGENEOUSCATALYTIC HYDROGENATION

FACE TO FACE Events

Heterogeneous catalytic hydrogenation is of significant importance for the production of pharmaceuticals, nutraceuticals, flavours and fragrances, agrochemicals and fine chemicals. Indeed, an average of approximately 10% of all chemical steps in the production of such chemicals are catalytic hydrogenations. However, due to the multidisciplinary nature of heterogeneous catalytic hydrogenation, this technology is frequently improperly or inadequately used, which results in problems during scale up and negatively affects the economy of chemical processes and the quality of products. Participants on this comprehensive course will be familiarized with all the important aspects of heterogeneous catalytic hydrogenation. COURSE OUTLINE

WHO SHOULD ATTEND?

• Organic Chemists – working in the pharmaceutical, agrochemical, flavours and fragrances, nutraceuticals and fine chemicals industries • Development and Production Chemists

Attendees will learn how to successfully design, develop and realize economic, safe, foolproof and ecological hydrogenation processes. The main focus will particularly be on a deeper understanding of the underlying disciplines such as catalysis on surfaces and transport processes. Guidelines on how to approach specific hydrogenation problems and concepts and tools for the design, development and scale up of catalytic hydrogenation processes will be presented, rather than summing up transformations of functional groups by catalytic hydrogenation, as this information can nowadays easily be searched and found in literature and patents.

HUNTSMAN “The course was very interesting. A lot of

information in a short time but it is very good to have seen all these relevant concepts. This was a very high quality course with an experienced tutor that masters the field. Thank you very much.”

ALMAC SCIENCES “A Tour de Force of

COURSE TUTOR”

Hydrogenation. A great course for organic chemists who have not got a strong background in surface chemistry. Packed with examples and tips.”

Dr Felix Roessler

WHEN &WHERE

BOOK WITH CONFIDENCE!

Dates 2021

Price

Location

26 – 27 October

€1,799.00

Milan, Italy

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION.

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

MEDICINALCHEMISTRY

FACE TO FACE Events

This course in medicinal chemistry sets out to train organic chemists to understand the key factors in discovering a new drug substance, from target selection, through lead generation and lead optimisation, to the selection of a development candidate. The course will cover aspects of the drug discovery process such as structure activity relationships, the use of computational chemistry in drug discovery, ADME and safety issue. The course also includes an overview of the use of computational chemistry in virtual screening and library design. COURSE OUTLINE

WHO SHOULD ATTEND?

The lectures are backed up by a number of case studies and workshop sessions, which involve the participants in using the concepts discussed.

• Young chemists who have just started in industry as medicinal chemists. • Experienced medicinal chemists who wish to gain additional knowledge on how to obtain compounds with optimal drug-like properties and get up to date with the latest thinking. • Chemists from other areas of Research and Development who would like to gain an appreciation of the processes and drivers involved in drug discovery. • Students who are planning a career in industry and can obtain company sponsorship

F. HOFFMAN LA ROCHE LTD DELEGATE 2019 “All the lecturers were excellent. This course is extremely valuable for my daily work. Congratulations! And thanks.”

COURSE TUTORS

Dr David Clark

Dr Will Watson

Dr Martin Swarbrick

Dr Paul Beswick

Dr Rachael White

WHEN &WHERE

BOOK WITH CONFIDENCE!

Dates 2021

Price

Location

22 - 24 June

€2,099.00

Hamburg, Germany

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION.

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

MODERNSYNTHETICORGANIC REACTIONS

FACE TO FACE Events

Driven by the increasing complexity of synthetic targets and the need for efficient, selective and environmentally benign synthetic methods, the past decade has seen tremendous innovation and reaction understanding in the field of synthetic organic chemistry. However, much like the transition of a molecule from discovery to development, the transition and application of new synthetic methodology from a research setting to an industrially relevant context can be challenging. COURSE OUTLINE

WHO SHOULD ATTEND?

• Discovery/Synthetic organic chemists • Process development chemists • Anyone wishing to learn more about essential new synthetic chemistry methodology and its potential application in an industrial setting • Academics who wish to understand how industrial and process chemists view new synthetic chemistry and what can be done at the discovery stage to make the technology scalable.

This course is designed to look in detail at essential new synthetic chemistry methodology and its potential application in addressing key challenges in industry. New processes will be presented with case studies and examples. In addition, an understanding of what it takes to transfer technology from an academic to a larger scale industrial context will be discussed.

COURSE TUTORS

Dr John Studley

Dr Will Watson

WHEN &WHERE

BOOK WITH CONFIDENCE!

Dates 2021

Price

Location

30 November – 2 December

€2,099.00

Basel, Switzerland

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION.

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

KINETICMODELLING: WHAT’S INITFORMEAND HOWTOGETSTARTED

NEW COURSE

ONLINE Events

This is a NEW Online Short Course – Reaction kinetic models can provide critical process understanding, and speed the development of robust and optimized Active Ingredient processes for scale-up. This short course provides an introduction to key aspects of physical organic chemistry and how they can be applied in a kinetic modelling approach. The course features case studies from the pharmaceutical industry and COURSE OUTLINE

Process development chemists who want to improve their understanding of physical organic chemistry and reaction kinetics. WHO SHOULD ATTEND?

its chemical supply chain, hands-on exercises and includes an optional day of further hands-on training with Reaction Lab™ software, the leading kinetic modelling platform for chemists in the pharmaceutical industry. This course will be set over two days with an optional demonstration session on Reaction Lab™

COURSE TUTORS

Dr Charles M Gordon

Dr Will Watson

WHEN &WHERE

Dates 2021

Price

Location

23 - 25 March 1.30-5.00pm (UK) Each Day £595.00 + VAT Online

This course is run in conjunction with

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

MOLECULETOMEDICINE

NEW COURSE

FACE TO FACE Events

The aim of this course is to provide attendees with a good basis to work from when involved in taking development candidates to the first in human trials with a view also on some longer-term requirements. The course content will therefore focus on the necessary early phases of chemical development as would typically be required to support production of up to about 2kg using laboratory-based 20L equipment and pilot plant equipment. The course will introduce and discuss the following: • Requirements in order to move from small (<1g) supplies to the first 100g or so for preclinical work • Further scaling to 1-2kgs non-cGMP COURSE OUTLINE

WHO SHOULD ATTEND?

• Project managers and those involved in technical outsourcing • Project leaders and bench chemists involved in preparation of material • New starters to the area • Medicinal Chemistry support teams involved in making the first batches for toxicological evaluation

• Requirements to make material for use in clinical trial – an introduction to cGMP coupled with the scaling issues • An overview of the requirements to move processes to fixed vessels, assuming cGMP is required – what operations can readily be transferred and those that should ideally be developed out • The importance of physical form selection, understanding and control • Impurities and their control, with specific discussion on genotoxic impurities and developing the specification for the API as it moves from preclinical batch preparation to cGMP batches for clinical trials.

GENENTECH DELEGATE “I am not a chemist, however, the course was very informative and it allowed me to see the big picture from discovery stage to pilot plant.”

COURSE TUTOR

Dr John Studley

WHEN &WHERE

BOOK WITH CONFIDENCE!

Dates 2021

Price

Location

1 8 - 20 May

€1,799.00

Madrid, Spain

FULL REFUNDS GIVEN ON FACE TO FACE MEETINGS IF WE ARE NOT ABLE TO RUN THE COURSE OR YOU ARE NOT ABLE TO TRAVEL DEPENDING ON THE CURRENT PANDEMIC SITUATION.

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

ORGANOCATALYSIS SHORTCOURSE

ONLINE Events

Over the past decade, the application of small-molecule organic catalysts to solve synthetic problems has gained traction in both industrial and academic settings. A wide and expanding range of catalyst classes and diverse activation modes in combination with increased mechanistic understanding and practical applicability has fuelled their use across many areas of synthesis, including asymmetric catalysis and construction of important chiral molecules and building blocks. COURSE OUTLINE

This online class will be of interest to organic chemists- both in industry and academia- and anyone interested in finding out more about this important area of catalysis. WHO SHOULD ATTEND?

Small molecule organic catalysts offer a range of practical advantages over macromolecular (enzyme) or precious metal catalysts, including air and water stability, low cost, availability from renewable resources and relatively low toxicity. Organocatalysis is recognised as an inherently green technology and often has no counterpart in the more established catalysis regimens.

COURSE TUTOR

Dr John Studley

WHEN &WHERE

Dates 2021

Price

Location

24 - 25 February 2.30-5pm (UK) Each Day £255.00 + VAT Online

FEE INCLUDES: • Live interactive training sessions based over 4 afternoons (UK time) using an online webinar platform • E Reader version of the manual (professionally printed versions of the manual are available but at an additional cost to cover postage) • Course certificate

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

co create

let’s

Working together to create cutting-edge chemistry

We are committed to providing you with full access to our unique catalyst technologies, helping to enhance your capabilities in high-quality synthesis. Our leading metathesis and cross-coupling portfolios include a comprehensive range of Umicore’s Grubbs catalysts ® for metathesis reactions, and the latest Buchwald and Hazari cross-coupling precatalysts. Together, let’s co-create more efficient, cost-effective and sustainable chemistries. Let’s co-create to make a difference l pmc.umicore.com

PHOTOREDOXCATALYSIS INORGANICSYNTHESIS

ONLINE Events

Light-driven organic synthesis, and in particular the use of visible light in photoredox catalysis, has dramatically increased over the past decade. COURSE OUTLINE

WHO SHOULD ATTEND?

Industrial application of photoredox and concomitant development of enabling technologies such as continuous flow photochemistry is also set to impact future drug manufacturing. The aim of this short course is to highlight the principles of photocatalytic transformations, summarize the available synthetic methodology and future challenges and examine industrial case studies.

• Discovery/Synthetic organic chemists • Process development chemists • Anyone wishing to learn more about photoredox chemistry

Application in synthetic drug discovery has expanded and

augmented the rapid diversification of chemical space- with new scaffolds, late stage functionalization and high throughput screening methods being used to identify new reaction modalities.

COURSE TUTOR

Dr John Studley

WHEN &WHERE

Dates 2021

Price

Location

27 - 28 May 2.30-4.00pm (UK) Each Day £255.00 + VAT Online

FEE INCLUDES: • Live interactive training sessions based over 4 afternoons (UK time) using an online webinar platform • E Reader version of the manual (professionally printed versions of the manual are available but at an additional cost to cover postage) • Course certificate

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

PHYSICALORGANICCHEMISTRY CONCEPTSFORPROCESS DEVELOPMENT

ONLINE Events

The scientific principles related to the optimisation of chemical processes so that they can be transferred from the laboratory to plant scale with minimal risk is an often underappreciated aspect of process development chemistry. Relevant physical organic chemistry principles are not widely taught in standard academic chemistry courses and are generally gained with experience – either through knowledge transfer within companies or through trial and error after mistakes have been made. Based on the work of Prof John Atherton, this course provides an introduction to some of the key physical organic chemistry principles that underpin chemical COURSE OUTLINE

WHO SHOULD ATTEND?

process development as well as the requirement for inter- disciplinary cooperation i.e. process development chemists, chemical engineers, analytical chemists etc. The theoretical concepts are supplemented with numerous examples to demonstrate different aspects of the relevant single- and multi-phase physicochemical science, exploring the potential impact of various phenomena on yield, selectivity and reaction rate.

Developed for on-line delivery, the course is targeted at organic chemists working in the fine chemical, agrochemical and pharmaceutical sectors and will be of benefit to laboratory process development chemists, laboratory managers and group leaders.

ONLINE ASTRAZENECA DELEGATE

Ran in conjunction with

“An excellent overview of the physical organic chemistry fundamentals that underpin process understanding – attending this training is a must for all aspiring process chemists!”

COURSE TUTORS

Dr Martin Edwards

Mr Robert Peeling

WHEN &WHERE

Dates 2021

Price

Location

14 – 16 September 2.00-5.00pm (UK) Each Day £255.00 + VAT Online

FEE INCLUDES: • Live interactive training sessions based over 4 afternoons (UK time) using an online webinar platform • E Reader version of the manual (professionally printed versions of the manual are available but at an additional cost to cover postage) • Course certificate

TO BOOK please either visit our website www.scientificupdate.com or email sciup@scientificupdate.com

www.scientificupdate.com

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