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CONTROL AND OPTIMIZE YOUR PROCESS

Optimize your crystallization process at an early stage with only small amount of material. C ombine the Crystal16 and Crystalline in a flexible configuration to optimize process success!

Solubility of Cloxacillin Benzathine in pure solvents 0

Screen for selecting solvents, polymorphs, salts or co-crystals has never been so easy after the introduction of the Crystal16 in 2005. The Crystal16 is a parallel crystallization platform that allows for fast screening of crystallization parameters in 16 parallel reactors with a volume of 1.5 mL. The Crystal16 can be used for the determination of solubility as a function of temperature in e.g. process development and optimization. After more than 10 years of success in more than 300 companies, it is, by far, the world’s most used equipment for solubility curves measurement and phase diagrams. Optimize your crystallization process at an early stage with only small amount of material. The Crystalline provides real time answers to all your questions related to process/manufacturing aspects, physicochemical properties, impurity profiling, particle size distribution and stability. W ith through the vial analytical capabilities including turbidity, particle visualization or Raman , it is easy to set up and operate.

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Monitoring particle count during crystallization

• Searching for less stable intermediates • Controlling growth of certain polymorphs • Develop and optimize your process • Real time information on chemical interactions • Drive reactions based on spectroscopic results • Measure relative reaction rates

Anti-solvent crystallization

Foaming

Oiling out

Crystallization

Agglomerates

Info@crystallizationsystems.com www.crystallizationsystems.com

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