BIOCATALYSIS–SOLVING SCALE-UP ISSUESWITH BIOCATALYSEDREACTIONS
COURSE OUTLINE Many forays by organic chemists into using biocatalysis in chemical synthesis stall at the initial scale- up stage. Screening and small scale (gram) reactions progress as planned, but when scaled -up, reactions stall, take more enzyme than expected, work-ups end up with emulsion issues etc. This course will look at some of the techniques and technologies ( tricks of the trade) that can help derisk scaling up biocatalysed reactions .A further barrier to the adoption of more biocatalytic reactions are production / EHS scientists who are unsure how to handle enzymes in the plant/pilot plant. the course will also look at good sources of information/data to facilitate the use of enzymes at scale.
• Enzyme supply chain: Storage, stability etc • Techno-economic analysis – will the transformation ever hit the required targets? • Different types of strains used and its safety impactions. • Using GMO’s and GMO derived materials • Handling concerns related to enzyme -SHE/EHS issues., Safety issues in scaling up biocatalytic reactions • Pros and cons of different enzyme formulations • Enzyme stability: General to pH, co-solvent, temperature as linked to process design and development • Enzyme analysis / characterisation – needed to assess purity in order to calculate activity and so expected long term cost, spec setting / quality control (ensure plant samples match lab samples and measure variation over time). • Scale-up – reactor options – various reactor types, std batch, continuous, membrane separated, continuous liquid extraction, etc • Product isolation from complex mix . Enzyme removal/ downstream
processing– to be intelligent in terms of what can and can’t be removed vs effects on process including downstream chemistry. • Use of immobilised enzymes/ Recycling of immobilised enzymes
VIRTUAL DELEGATE 2020 “I really enjoyed the virtual Short Course and it was very good incl. the thorough collection of examples etc. Looking forward to the next ones!”
Scientists working in medicinal/process chemistry and are interested in moving frommg/screening scale to 100’ s grams-multi kg scale. WHO SHOULD ATTEND?
Dr Andrew Wells
7 - 8 April 1.30 - 4.00pm (UK)
£295.00 + VAT Online
Please note: this course assumes some prior existing knowledge of biocatalysis / biotransformations as applied to synthetic organic chemistry, either in theory or some prior practical use at screening/ small scale laboratory experimentation, an appreciation of different enzyme classes etc.
TO BOOK please either visit our website www.scientificupdate.com or email firstname.lastname@example.org
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