FG-4592 induces intestinal stem cells markers
FG-4592
Veh FG-4592 Veh + 5 Gy FG-4592 + 5 Gy
⇧ intestinal stem
+4 stem cell markers
72h
Veh FG-4592 Veh + 5 Gy FG-4592 + 5 Gy
cell/crypt survival
+4 Quiescent stem cell marker
✱✱✱
✱✱✱✱
✱✱✱✱
✱
✱✱ ✱
✱
✱✱✱✱
Intestinal Organoid (Mini-Guts)
GI radioprotection
20
15
+4 Quiescent stem cell marker
✱✱✱
10
✱✱✱✱
✱✱✱✱
5
✱
✱✱ ✱
✱
✱✱✱✱
20
0
BMI
HOPX
DCLK1
MEX3A
TERT
15
MD ANDERSON CANCER CENTER
10
4
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