Summary • ATC tumor microenvironment is highly enriched with exhausted CD4+ T cells expressing PD-1, LAG3 and CTLA-4 • ATC tumors are infiltrated with immunosuppressive myeloid cells, cDC2 and M2 macrophages, expressing high levels of PDL1 • Treg cells changed phenotype towards inflammatory Th17 cells in ATC
Future directions
• Assess the contribution of immune cells to ATC pathogenesis
• Evaluate the efficacy of cell-targeted and immune checkpoint blockade therapy in ATC model
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