Characterization of Altered immunity in Anaplastic Thyroid …

Summary • ATC tumor microenvironment is highly enriched with exhausted CD4+ T cells expressing PD-1, LAG3 and CTLA-4 • ATC tumors are infiltrated with immunosuppressive myeloid cells, cDC2 and M2 macrophages, expressing high levels of PDL1 • Treg cells changed phenotype towards inflammatory Th17 cells in ATC

Future directions

• Assess the contribution of immune cells to ATC pathogenesis

• Evaluate the efficacy of cell-targeted and immune checkpoint blockade therapy in ATC model

Made with FlippingBook - Share PDF online