Early Clinical Trials Expertise
Key Pharmacodynamic Methods SGS has a full-time team of Investigators, Research Physicians, Study Nurses, Clinical Research Coordinators and Clinical Project Managers who are trained and experienced in various kinds of evaluations. They are also present to support hospital staff, and can provide specific equipment (eg. body box) to properly carry out the necessary measurements such as:
MECHANISMS OF ACTION • SABA, LABA, LAMA, ICS, LTB4 + PDE4 inhibitors, mast cell stabilizers and methylxanthines • New CRTH2 inhibitors and Monoclonal Ab, involving the TLR3 target At SGS we have implemented different ‘customized’ or ‘on-demand’ bronchial challenge models depending on the study/sponsor specific requirements.
METHODS • Spirometry • Whole body plethysmography • FeNO • Arterial blood gases • Capnography • Sputum induction • Bronchoalveolar lavage Bronchial challenge techniques like metacholine and LPS
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