Early Clinical Trial Expertise
Pharmacologic Methods Dedicated methods for evaluating the
• Respiratory evaluation techniques, including lung function, sputum induction, bronchoprovocation, bronchoalveolar lavage (BAL) and others
pharmacology of anti-infectious drugs performed for clinical trials in healthy subjects as well as in patients, such as: • PK in plasma, urine, feces, saliva, vaginal fluids/ mucosa and CSF • Cantharides-induced skin blister • In vitro, ex vivo bactericidal activity in blood, urine and tissue • Effect on the intestinal microflora • Tissue distribution / skin penetration • Pivotal clinical PK studies assessing the impact of renal and hepatic impairment on the disposition of antiinfectious drug as well as the potential for metabolic drug-drug interaction. • TQT trials
• Human inoculation with live viruses Analytical Laboratory Services
SGS has more than 60 validated bioanalytical methods for the determination of anti-infectious drug in plasma, urine and tissues that are readily available for the PK evaluation of comparators and interacting drugs. With experience in developing and validating new bioanalytical methods, SGS also provides services encompassing: • Biosafety testing • Biomarkers • Cell based & Immunoassays • Molecular virology and viral serology
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