CPhT CONNECT™ Magazine - Volume 5 Issue 2

ce teriflunomide

The NIOSH Hazardous Drug List

"Immunomodulatory agents"

No

No

testosterone

Androgen

No No

Yes

tofacitinib

"Disease-modifying antirheumatic drugs, immunomodulatory agents"

No

topiramate

Anticonvulsants, miscellaneous; antimi- graine agents, miscellaneous

No

Yes

toremifene

"Estrogen agonist- Antagonists, antineoplastic agents" Antineoplastic agents

No

Yes

trametinib tretinoin triptorelin ulipristal

No No No No

No

Cell stimulants and proliferants

Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes

Gonadotropins, antineoplastic agents

Contraceptives Gonadotropins

urofollitropin

Yes

valproate/valproic acid

Anticonvulsants, miscellaneous; an- timanic agents; antimigraine agents, miscellaneous

No

vemurafenib vigabatrin vismodegib voriconazole

Antineoplastic agents

No No No No No No

Anticonvulsants

Antineoplastic agents

Azole antifungal

warfarin

Coumarin derivatives

zidovudine

HIV nucleoside and nucleotide reverse transcriptase inhibitors

No

ziprasidone ziv-afibercept zoledronic acid

Atypical antipsychotics; antimanic agent No

No

Antineoplastic agents Bone resorption inhibitors

Yes

Yes Yes Yes

No No

zonisamide

Anticonvulsants, miscellaneous

**Previously Table 3. Group 3: Non-antineoplastic drugs that have adverse reproductive effects. ***Only an occupational developmental hazard in the third trimester of pregnancy

The following table list drugs that were either removed from the 2016 List after the 2016 update or were moved to a table that is different from the table on which they were placed in the 2016 List update. Refer to Table 4. Table 4 Changes to the Placement of Drugs from the 2016 List of Hazardous Drugs

Ergonovine

Ergonovine was never approved for use in humans by the FDA in the United States. NIOSH reviewed data from studies provided by the manufacturer and determined it is unlikely that liraglutide poses a carcino- genic, reproductive, or developmental hazard to workers in a healthcare setting and is no longer considered a hazardous drug by NIOSH. NIOSH reviewed data from studies provided by the manufacturer and de- termined it is unlikely that paliperidone poses a carcinogenic, reproductive, or developmental hazard to workers in a healthcare setting and is no longer con- sidered a hazardous drug by NIOSH.

Liraglutide

Paliperidone

Drug

Notation

Bacillus Calmette Guerin (BCG)

NIOSH removed BCG from the List because it is an infectious agent and not classified as a drug by FDA. For handling recommendations, see the drug package insert.

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