Kolling Institute Year in Review 2025

Cardiovascular, Renal and Metabolic Research

Wraparound support needed to lose weight and extend longevity

The key to long term weight loss and good health is not just a new, dynamic medication like Ozempic, but a much broader approach involving comprehensive support. This is a view held by leading endocrinologist and senior Kolling Institute researcher Professor Sarah Glastras, who is calling for a shift away from the perception that these new game-changing medications are the only answer to complex health challenges like obesity and heart disease. Professor Glastras is part of a growing body of health professionals advocating for a holistic approach to weight loss, involving a multi- disciplinary team including an endocrinologist, dietitian, exercise physiologist and counsellor when necessary. New evidence is emerging around the risk of weight gain once the medication is stopped, and the potential loss of lean muscle in people who have rapid weight loss without adequate nutrition support. Professor Glastras says these risks can be reduced with a tailored health program, encompassing exercise, particularly resistance training, education and healthy diet support. “If we’re going to be able to make leaps and bounds in the space of weight management, not just for the individual, but for their family and their children, it has to be a lot more holistic than just the medication,” she said. “I’m very much in favour of being able to access all the team players.

Professor Sarah Glastras

“Hopefully, we’ll see better wraparound care going forward, including a national approach to adequate resources to make sure that weight loss programs are structured and holistic. “We’re running a lot of clinical trials at Royal North Shore Hospital in this area, and these trials offer a good opportunity to receive greater support.” The hospital’s Diabetes and Obesity Clinical Trial team is running clinical trials focusing on long-term weight management. One study is for adults who have obesity with a Body Mass Index (BMI) over 30 - or are overweight with a BMI over 27 and a health condition such as high blood pressure or prediabetes, and do not have type 2 diabetes. Professor Glastras said by taking part, you could help advance treatments for weight management and progress medical research, while also benefitting from a carefully monitored program. “Weight management is a life-long journey and our team enjoys helping people along their road to good health outcomes.”

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