Immune microenvironment dysfunctions enable malignification at the onset of MDS Ganan-Gomez I, Ma F, Chien KS, Yang H, Montalban-Bravo G, Wildeman BE, Kumar B, Kim YJ, Daher M, Takahashi K, Garcia-Manero G and Colla S
2. Inhibitory Crosstalk Predicted Between NK and CD8 + T Cells in CCUS
3. CCUS NK/T Cells Are Terminally Differentiated toward Exhaustion
scRNA-seq in sorted CD3 + T and CD56 + NK cells
CellPhoneDBanalysis of DEGs
NK cell activation by CD8 + T cells HLA-E:CD94/NKG2C CD58:CD2 FASLG:TNFRSF1A
CCUS (n=3) Elderly HD (n=2) Young HD (n=2)
Ligand-expressing cells
NK
CD4 T
CD8 T
CytoTRACE differentiation scores Exhaustion marker expression
CCUS Elderly Young
Receptor-expressing cells
Immunosuppresion of CD8 + T cells by NK cells CD48:CD244 TGFB1:TGFBR1
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