Shared Nearest Neighbors Approach

ICON data network highlights new connections based on interplay between integrated platforms Selection of SNN with RNA-based edges Improved performance over SNN, RNA alone SNN platforms provide more edges per node Overlaps in network edges from each platform shown Community detection identifies modules 10 top-level and 93 mid-level modules with 10+ genes

SNN (Flow, RPPA) only

Network of highest- level phenomena

SNN (Flow, RPPA) + RNA

Intermediate phenomena

RNA only

Individual genes at deepest layer


Schmidt, et al. JCO Clinical Cancer Informatics no. 6 (2022) e2200040.

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