READY-TO-LOAD™ DNA ELECTROPHORESIS
2024-2025 EDVOTEK ® RESOURCE GUIDE
Cat. #115 Cancer Gene Detection
For 8 Gels/8 Lab Groups. Immortality through uncontrolled cell divi- sion is a characteristic of cancer cells. The p53 gene is a tumor sup- pressor gene which prevents this. Mutations in this gene are present in more than 50% of cancers. Testing people for mutations in their p53 gene can indicate an increased risk for developing cancer. These tests raise intriguing ethical questions for both the individual tested and the family of an individual who chooses to be tested. In this experiment, students determine a pedigree for a family suspected to be carriers of mutations in their p53 genes. A DNA test indicates their likelihood of developing cancer.
ALSO Available: Full Experiment featuring SYBR® Safe DNA Stain DNA Samples Only in QuickStrips™ for 8 gels DNA Samples Only in Microtest Tubes for 24 gels
Cat. #115-S Cat. #115-A Cat. #115-C
Cat. #116 Sickle Cell Gene Detection (DNA-based)
For 8 Gels/8 Lab Groups. Sickle Cell Anemia is a common genetic disease that causes long rods in red blood cells, giving them a “sickled” appearance. These cells get stuck in small capillaries of the blood stream leading to oxygen deprivation that causes pain and organ damage. Sickle Cell Anemia is caused by a single point mutation in the hemoglobin gene that results in a faulty protein. In this experiment, your students will investigate the restriction enzyme that discriminates between HbA (normal) and HbS (disease) genes and perform a simulated test on a patient.
ALSO Available: Full Experiment featuring SYBR® Safe DNA Stain DNA Samples Only in QuickStrips™ for 8 gels DNA Samples Only in Microtest Tubes for 24 gels
Cat. #116-S Cat. #116-A Cat. #116-C
Cat. #117 Detection of Mad Cow Disease
For 8 Gels/8 Lab Groups. Bovine spongiform encephalopathy (BSE), better known as mad cow disease, is a neurodegenerative, fatal condition in cattle. Consuming BSE-infected beef is believed to be the cause of a similar condition in humans, Creutzfeldt-Jakob disease. In this experiment, students examine simulated PCR products from several feed mills, to determine any possible violations of a 1997 ban which ended the practice of including animal parts in cattle feed.
ALSO Available: Full Experiment featuring SYBR® Safe DNA Stain DNA Samples Only in QuickStrips™ for 8 gels DNA Samples Only in Microtest Tubes for 24 gels
Cat. #117-S Cat. #117-A Cat. #117-C
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