Determination of inorganic anions in drinking water by Ion Chromatography
EPA Method 300.1
DETERMINATION OF INORGANIC ANIONS IN DRINKING WATER BY ION CHROMATOGRAPHY
Revision 1.0
John D. Pfaff (USEPA, ORD, NERL) Method 300.0 (1993) Daniel P. Hautman (USEPA, Office of Water) and David J. Munch (USEPA, Office of Water) Method 300.1 (1997)
NATIONAL EXPOSURE RESEARCH LABORATORY OFFICE OF RESEARCH AND DEVELOPMENT U.S. ENVIRONMENTAL PROTECTION AGENCY CINCINNATI, OHIO 45268
WITH NOTES FROM
The Technical Team at Inorganic Ventures
All copyright held in respect of the EPA’s Method 300.0/300.1 remains solely with the U.S. Environmental Protection Agency. Notations added herein to the EPA Method 300.0/300.1 serve solely as commentary prepared by the staff at Inorganic Ventures and do not represent the opinion of the method authors, including but not limited to the Environmental Monitory Systems Laboratory, the Office of Research and Development or the U.S. Environmental Protection Agency generally. Furthermore, Inorganic Ventures does in no way claim any rights in or to the content of the EPA’s Method 300.0/300.1 by adding notations therein.
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
Analyzing unfamiliar samples can be challenging due to the possible presence of unknown analytes. Fortifying your sample with your analytes of interest can help determine if the peaks in the sample are truly your analytes of interest or separate unknown analytes.
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
Treatment of the sample with strong base may reduce the loss of bromide and nitrite if added soon after the sample has been treated with disinfectants. There are several columns that are commercially available that will allow for the analysis of both Part A & B analytes. We have had great success using the AS22 column from Thermo or the Metrosep A Supp 5 column from Metrohm.
Modern IC instrumentation may allow for smaller injection volumes especially when using capillary columns.
You can gain a higher confidence in your check solutions by using a second-source standard compared to the standards used to construct your calibration curve.
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
Need an IC Standard with concentrations unknown to your analysts? Contact our Custom Product Development Team for product options!
Contact us for primary and
secondary source product options!
This surrogate analyte serves as an internal standard to check for any impact to your results because of your sample matrix when compared to the clean matrix of your standards.
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
Many low molecular weight organic analytes will have a similar retention time as fluoride. You can run high purity single analyte standards to help identify fluoride
Be cautious if perchlorate is present in your
from possible interferences.
sample. We have seen perchlorate have an extremely long retention time, greater than 40 minutes, when running an IC optimized for part A and B analytes.
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
1000 mg/L stock standard solutions are available as ISO:17034 Certified Reference Materials from Inorganic Ventures as stock products. We have a range of eluent concentrates available also!
Make sure to check the cleanliness of your sample bottles. This is especially critical if you change vendors.
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
Our 1000 ppm Chlorite (ICCLO21) stock standard is typically 98+% pure, containing extremely low levels of chloride and chlorate.
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
IV CRMs are stable for up to 5 years when stored in our Transpiration Control Technology (TCT) packaging. Once open our standards are good to use for 12 months!
500 ppm DCA is also available as a stock standard (ICDCA-S).
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
More information on MDLs can be found Code of Federal Regulations, Title 40. MDLs can be difficult to assign accurately. You will have to look into the noise of your instrument signal and overlaying replicate data may help determine actual peaks from baseline noise. Feel free to reach out to info@inorganicventures.com for Technical Support
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
Once you have validated your method. Ask about our custom CRM products. We can provide ready-to-use or concentrated blends containing your selected analytes at concentrations dictated by your method.
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
See our Trace Analysis Guide for more tips to help prevent lab contamination!
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
EPA Method 300.1 Determination of Inorganic Anions in Drinking Water by Ion Chromatography
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