The brochure highlights Avanti Research's capabilities in lipid-based formulation development, offering comprehensive services from R&D to commercial production. It details our expertise in creating custom lipid formulations, scaling up manufacturing processes, and supporting clinical trials. Our Formulation Experts collaborate closely with clients to design, optimize, and produce lipid-based drug delivery systems. Our facilities include state-of-the-art equipment for various manufacturing techniques, ensuring high-quality results at every stage of product development. For more detailed information, you can view our full brochure here.
Liposomes & Nanoparticles What happens when your research partner is with you all the way? Discover the difference
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At the commercial stage Formulations
At the R&D stage
The Avanti Formulations Team can help develop a suitable formulation for your lipid-based formulation. With the vast library of Avanti lipids and state-of-the-art equipment at our disposal, this experienced team can produce surface-labeled, PEGylated, fluorescent, and other lipid formulations, while working closely with our Lipid Analysts to ensure Avanti quality. Let us help you do amazing things with our lipids! • Discovery • Proof of concept • Small scale manufacturing • Process scale-up • Clinical trials • Commercial realization The Avanti formulations division can help you at each step. To find out more about how we may assist you with your liposome or nanoparticle needs, please contact us at: liposomes@avantilipids.com
Our formulations division offers complete product cycle services that support oral formulations for commercial production. For parenteral products, we have established relationships with sterile lipid formulation product manufacturers for a seamless transfer of your product to aseptic commercial production. Commercialization process: • Transfer our small-scale manufacturing to larger- scale (1 L – 55 L batches) • Manufacture materials for clinical trials in our animal product-free, cGMP manufacturing area • Manufacture adjuvant-containing liposomes or nanoparticles in our cGMP adjuvant manufacturing suite • Assist in the identification and selection of a sterile-filtration facility for parenteral products • Coordinate inter-departmental efforts including analytical method development, qualification and validation, stability, and regulatory support
The process starts at the R&D stage. Our Formulations Team has considerable experience working with Avanti lipids to produce lipid formulations with the exact properties you need for a successful project. Whether you have developed your own formulation and need help scaling up the process, or you want Avanti to design a lipid-based drug delivery system to achieve your product goals, we have the capability to design and deliver any formulation imaginable. And if the perfect lipid for your formulation does not currently reside in our extensive catalog, chances are our outstanding lipid synthesis team can prepare it. R & D process: • Offer formulation expertise and assist in the design of lipid-based formulations • Provide the full Avanti lipid catalog for custom formulations as small as 25 mg • Provide custom synthesis of lipids for your formulation • Make custom lipid formulations to meet your specifications or prepare custom lipid blends • Provide lipid-based drug delivery systems that encapsulate, conjugate, or complex APIs, nucleic acids, proteins, and small molecules. • Produce 1 mL – 50 L lipid formulations using: • Extrusion • High-pressure Homogenization • Sonication • High-shear Homogenization • Microfluidics
Polyethylene glycol Ligand DNA/RNA/siRNA Phospholipid
Hydrophilic drug Crystalline drug Hydrophobic drug Surface-conjugated drug
At the clinical stage
The clinical process starts with the assignment of a dedicated Project Manager, ensuring that your project is completed within your expected timeline. Your Project Manager works in partnership with you through the following process. Clinical process: • Transfer our small-scale manufacturing to larger- scale (1 L – 55 L batches) • Manufacture materials for clinical trials in our animal product-free, cGMP manufacturing area • Manufacture adjuvant-containing liposomes or nanoparticles in our cGMP adjuvant manufacturing suite • Assist in the identification and selection of a sterile-filtration facility for parenteral products • Coordinate inter-departmental efforts including analytical method development, qualification and validation, stability, and regulatory support
www.avantiresearch.com
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@AvantiResearch
Avanti Research
liposomes@avantilipids.com
www.avantiresearch.com
Non-warranty The information in this publication is believed to be accurate and is given in good faith, but no representation or warranty as to its completeness or accuracy is made. Suggestions for uses or applications are only opinions. Users are responsible for determining the suitability of these products for their own particular purpose. No representation or warranty, expressed or implied, is made with respect to information or products including, without limitation, warranties of merchantability, fitness for a particular purpose, non-infringement of any third-party patent or other intellectual property rights including, without limit, copyright, trademark and designs. Unless otherwise stated, any trademarks identified herein are trademarks of the Croda group of companies. Avanti Research is a trademark of Croda international Plc. Avanti Research is a Croda brand associated with Avanti Polar Lipids, LLC.
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