SPLASH Brochure

SPLASH™ BOOSTER Product number 330740-1EA

New product

Concentration (µg/mL)*

Compound name

Molecular weight

Exact mass

Chemical formula

15:0-18:1 (d7) PA (Na Salt)

689.927

689.499

C 36 H 61 D 7 NaO 8 P C 31 H 56 D 7 NO 3 C 39 H 68 D 7 NO 8 C 45 H 78 D 7 NO 13

5.4

C13-dihydroceramide-d7 (d18:0-d7/13:0)

504.88

504.52

1.0

C15 Glucosyl (B) Ceramide-D7 (d18:1-D7/15:0)

693.06

692.59

4.2

C15 Lactosyl (B) Ceramide-d7 (d18:1-D7/15:0)

855.21

854.65

5.6

Oleic acid-d9

291.517

291.312

C 18 H 25 D 9 O 2

4.5

*Concentrations are based on the isotopic purity of each individual compound

MSI SPLASH ™ Product number 330841

As the role of lipids in neurodegenerative diseases such as Parkinson’s Disease is increasingly acknowledged, it has become essential to consider what lipids may have a hand in neuropathology. MSI SPLASH is made specifically for Mass Spec Imaging of neurological tissue. The mixture of thirteen internal standards is designed to be applied to brain sections using a sprayer, similarly to the application of matrix for MALDI. MSI SPLASH allows not only for quantitation of lipids within the brain, but also localization of those lipids to provide more detailed information for answering biological questions. This mixture was designed in collaboration with Michiel Vandenbosch, Shadrack Mutuku, Shane Ellis & Kim Ekroos. Toward Omics-Scale Quantitative Mass Spectrometry Imaging of Lipids in Brain Tissue Using a Multiclass Internal Standard Mixture. Michiel Vandenbosch, Shadrack M. Mutuku, Maria José Q. Mantas, Nathan H. Patterson, Tucker Hallmark, Marc Claesen, Ron M. A. Heeren, Nathan G. Hatcher, Nico Verbeeck, Kim Ekroos, and Shane R. Ellis. Analytical Chemistry 2023 95 (51), 18719-18730 DOI: 10.1021/acs.analchem.3c02724

Compound name

Exact mass Chemical formula Target conc (µM)

Target conc (µg/mL)

15:0-18:1 (d7) PA

689.499

C 39 H 69 D 5 NaO 10 P C 41 H 73 D 5 NaO 10 P C 43 H 73 DD 5 NaO 10 P C 45 H 75 DD 5 NaO 10 P C 37 H 64 D 5 NNaO 10 P C 39 H 68 D 5 NNaO 10 P C 41 H 72 D 5 NNaO 10 P C 43 H 72 D 5 NNaO 10 P C 45 H 74 D 5 NNaO 10 P

159.44

0.11

15:0-18:1 (d7) PE

710.559

140.64

0.1

15:0-18:1 (d7) PG

763.536

64.14

0.049

15:0-18:1 (d7) PI

846.596

27.15

0.023

17:0-16:1 PS-d5

774.52

135.48

0.105

17:0 Lyso PE-d5

472.33

6.35

0.003

C12 Mono-sulfo galactosyl(beta) ceramide (d18:1/12:0)

740.486

25.64

0.019

C15 Lactosyl(beta) ceramide-d7 (d18:1/15:0)

854.65

15.2

0.013

C18 Ceramide-d7 (d18:1/18:0)

572.587

19.2

0.011

C17 Glucosyl(beta) Ceramide (d18:1/18:0)

713.581

C 34 H 59 D 5 O 5 C 36 H 63 D 5 O 5 C 38 H 67 D 5 O 5 C 40 H 67 D 5 O 5

186.26

0.133

SM d18:1/18:1(d9)

737.64

42

0.031

17:0 Lyso PC-d5

514.38

5.83

0.003

15:0-18:1 (d7) PC

752.606

213.79

0.161

5

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