Bomfim 2024 | Anti-inflammatory
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Bomfim FRCD, Gomes BS, Lanza SZ, Esquisatto MAM, Lopes-Filho GJ. Photobiomodulation effects on synovial morphology, iNOS gene, and protein expression in a model of acute inflammation. Acta Cir Bras. 2024 Mar 15;39:e392024.
Laboratory animal study. Methods: 36 female Wistar rats were assigned into 3 groups: • Control (saline, no arthritis induction, n = 12), • Sham (arthritis induction, sham photobiomodulation, n = 12), • PBM (arthritis induction and photobiomodulation, n = 12). In the PBM group, a single dose of PBM was performed 24 h after induction with a laser device. In the sham and control group the device was turned off. Results • An increase in the thickness of the synovial lining epithelium and inflammatory infiltrate in sham compared to PBM was observed. • Gene expression analysis showed higher iNOS gene expression in PBM, while iNOS protein expression decreased in PBM compared to sham. • This suggests a secondary mitochondrial stimulation that can promote an increase of antioxidant enzyme balance or decrease of neutrophils migration that can be observed in morphological analyses with higher inflammatory infiltration without treatment.
KEY MESSAGE Photobiomodulation decreased inflammation in animals with induced arthritis, upregulated iNOS gene expression, however downregulated protein expression compared to sham.
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