Naterstad 2018 | Anti-inflammatory
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Naterstad IF, Rossi RP, Marcos RL, Parizzoto NA, Frigo L, Joensen J, Lopes Martins PSL, Bjordal JM, Lopes-Martins RAB. Comparison of Photobiomodulation and Anti-Inflammatory Drugs on Tissue Repair on Collagenase-Induced Achilles Tendon Inflammation in Rats. Photomed Laser Surg. 2018 Mar;36(3):137-145.
Animal laboratory study . Methods : 205 Wistar rats were randomly divided into 5 groups: • Healthy control : were given a saline injection • Injury + no treatment • Injury + LLLT (3 J, 810 nm, 100 mW) • Injury + NSAID (diclofenac 1.1 mg/kg) • Injury + dexamethasone (0.02 mg/kg) Experimental groups received a collagenase injection (100 μg /tendon) in the peritendinous Achilles to induce tendinitis. Histological analyses included an assessment of the severity of inflammation, collagen fiber content, and collagen organization. Results : • Collagenase injection induced a severe inflammatory reaction with significant reduction in collagen content for 48 h, and disorientation of collagen fibers lasting between 14 and 21 days. • Diclofenac and dexamethasone reduced inflammatory signs during the first 2 days, although there was prolongation of the inflammatory phase and slower normalization of tendon quality, particularly in the dexamethasone group.
KEY MESSAGE: LLLT showed a significant superiority over commonly used anti-inflammatory pharmaceutical agents in acute collagenase-induced tendinitis for reducing early inflammatory markers, preventing hemorrhage and preserving tendon morphology.
Pubmed
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• LLLT prevented hemorrhage, reduced inflammation severity, and preserved tendon morphology compared with the other groups.
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