Bjordal 2010 | Anti-inflammatory
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Bjordal JM, Lopes-Martins RA, Joensen J, Iversen VV. The anti-inflammatory mechanism of low level laser therapy and its relevance for clinical use in physiotherapy. Physical Therapy Reviews 2010;15(4):286-293.
Systematic review Studies : 11 cell studies and 27 animals studies met all inclusion criteria, and another 6 animal studies met the inclusion criteria for drug comparisons and LLLT interactions. Results : - There is strong evidence of an anti-inflammatory effect from LLLT, which is consistent across all 12 tested laboratory models and phases of inflammation and wavelengths between 633 and 904 nm. - The magnitude of the anti-inflammatory effect is not significantly different from that of non-steroidal anti- inflammatory drugs (NSAIDs), but it is slightly less than glucocorticoid steroids. - There is moderate evidence that concomitant use of glucocorticoid steroid has a negative effect on LLLT mechanisms and should be avoided.
KEY MESSAGE: There is strong evidence that red and infrared LLLT has a dose-dependent anti-inflammatory effect in animals, and scant evidence that the anti-inflammatory effect also occurs after LLLT in humans. The magnitude of the effect is not significantly different from NSAIDs
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