Alves 2014 | Muscle repair
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Alves AN, Fernandes KP, Deana AM, Bussadori SK, Mesquita-Ferrari RA. Effects of low-level laser therapy on skeletal muscle repair: a systematic review. Am J Phys Med Rehabil. 2014 Dec;93(12):1073-85.
Systematic review of 17 studies on the use of LLLT for the repair of skeletal muscle in any animal model. Results : • LLLT has been shown to be an extremely efficient therapeutic resource for the modulation of the inflammatory process and the attenuation of oxidative damage after muscle injury. • LLLT has shown promise in modulating MRFs (myogenic regulatory factors). • LLLT has been shown to be effective in modulating the formation of fibrotic tissue during the repair of injured muscle tissue. It has been shown to be effective in reducing the gene expression of TGF- β which plays a key role in the initiation of fibrotic cascades and the differentiation of satellite cells into myofibroblasts in injured muscle. • LLLT is extremely effective in modulating the expression of VEGF mRNA and the consequent formation of new blood vessels during the repair of injured skeletal muscle.
The main effects of LLLT in muscle injuries were a reduction in the inflammatory process, the modulation of growth factors and myogenic regulatory factors, remodelling of extracellular matrix, and increased angiogenesis.
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