Luo 2013 | Muscle repair
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Luo L, Sun Z, Zhang L, Li X, Dong Y, Liu TC. Effects of low-level laser therapy on ROS homeostasis and expression of IGF-1 and TGF- β1 in skeletal muscle during the repair process. Lasers Med Sci. 2013 May;28(3):725-34.
Animal laboratory study Methods : Adult male Sprague-Dawley rats (n=96) were randomly divided into three groups: control group (no lesion, untreated, n=6), contusion group (n=48), and contusion-plus-LLLT group (n=42). Muscle remodelling was evaluated at 0 h and 1, 2, 3, 7, 14, 21, and 28 days after injury. Results : • LLLT markedly promoted the regeneration of muscle and reduced scar formation. • LLLT also significantly enhanced muscle SOD (muscle superoxide dismutase) activity and significantly decreased muscle MDA (malondialdehyde) levels 1, 2, and 3 days after injury. • LLLT increased the expression of IGF-1 2, 3, and 7 days after injury and decreased the expression of IGF-1 21 and 28 days after injury. • LLLT decreased the expression of TGF- β1 3 and 28 days after injury but increased expression at 7 and 14 days after injury.
This study showed that LLLT could modulate the homeostasis of ROS (reactive oxygen species) and of the growth factors IGF-1 and TGF- β 1, which are known to play important roles in the repair process. This may constitute a new preventive approach to muscular fibrosis.
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