Photobiomodulation Clinical Evidence

Cai 2023 | Knee OA

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Cai P, Wei X, Wang W, Cai C, Li H. High-intensity laser therapy on pain relief in symptomatic knee osteoarthritis: A systematic review and meta-analysis. J Back Musculoskelet Rehabil. 2023;36(5):1011-1021.

Systematic review and meta-analysis. 9 RCTs investigating the effectiveness of HILT compared to other laser therapies, conventional therapies or exercises on knee OA pain were included. 7 studies had good to excellent methodological quality. Results All studies reported positive effects of High-Intensity Laser therapy on knee osteoarthritis pain. • 2 studies (136 people) showed HILT was more effective for pain relief than sham laser therapy in a short-term treatment (MD, -2.04, 95% CI, -2.12 to -1.96; Z= 51.01, P< 0.01). • 4 studies (160 people) showed that HILT was more effective for decreasing VAS score than conventional physiotherapies (MD, -0.98, 95% CI, -1.19 to -0.76; Z= 9.02, P< 0.01).

KEY MESSAGE High-Intensity Laser therapy could be a promising and recommended modality in alleviating knee osteoarthritis pain, especially when it was implemented in combination with exercises.

• 3 studies (123 people) demonstrated that HILT combined with exercises was more effective than placebo laser or lower-intensity laser combined with exercises in alleviating pain in patients with knee osteoarthritis (MD, -1.54, 95% CI, -1.84 to -1.24; Z= 10.06, P< 0.01).

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