Ketz 2017 | Analgesia
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Kobiela Ketz A, Byrnes KR, Grunberg NE, Kasper CE, Osborne L, Pryor B, Tosini NL, Wu X, Anders JJ. Characterization of Macrophage/Microglial Activation and Effect of Photobiomodulation in the Spared Nerve Injury Model of Neuropathic Pain. Pain Med. 2017 May 1;18(5):932-946.
Animal laboratorystudy -
Subjects : 33 Sprague-Dawley rats - Sham surgery (n=13) - SNI surgery (n=13) - SNI surgery + LiteCure PBM treatment (n=7) - PBM (980 nm) protocol :
- Affected hind paw: 1 W, 20 s, 41cm above skin, dose 20 J - Dorsal root ganglia: 4.5W, 19s, skin contact, dose 85.5 J - Spinal cord regions 1.5 W, 19s, skin contact, dose 28.5 J - Every other day from day 7-30 post-operatively.
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Results : - Injured groups demonstrated mechanical hypersensitivity 1-30 days post- operatively. - Photobiomodulation-treated animals began to recover after two treatments; at day 26, mechanical sensitivity reached baseline. - Peripheral nerve injury caused region-specific macrophages/ microglia activation along spinothalamic and dorsal-columnmedial lemniscus pathways. - A pro-inflammatorymicroglial marker was expressed in the spinal cord of injured rats compared to photobiomodulation-treated and sham group. - Photobiomodulation-treated dorsal root ganglion macrophages expressed anti-inflammatory markers.
KEY MESSAGE: Photobiomodulation effectively reduced mechanical hypersensitivity, potentially through modulating macrophage/microglial activation to an anti-inflammatory phenotype
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