Holanda 2017 | Analgesia
Back to overview
Holanda VM, Chavantes MC, Wu X, Anders JJ. The mechanistic basis for photobiomodulation therapy of neuropathic pain by near infrared laser light. Lasers Surg Med. 2017 Jul;49(5):516-524.
7 In vitro experiments showed decreased mitochondrial activity and formation of varicosities and undulations in neurites of DRG neurons which is a morphological indication of microtubule disruption of the pain afferents, slowing down transmission of pain signals. This specific mechanism helps explain how pain complaints can be reduced quickly after high power treatments in superficial tissues. • In vivo experiments showed significant reduction in sensitivity to heat, cold and mechanical stimulus post-laser treatment. Laboratory study . Methods: using in vivo and in vitro experimental models, this study determined the mechanistic basis of photobiomodulation therapy (PBMT) for the treatment of neuropathic pain using a high irradiance (≥ 270 mW/cm²). Specifically, neuroplastic mechanisms that take place at peripheral sensory nerves (A δ and C-fibers) when high irradiance is applied. Results : •
KEY MESSAGE: These in vitro and in vivo studies indicate that treatment with an irradiance at 270 mW/cm2 or higher at the level of the nerve can rapidly block pain transmission. A combination therapy is proposed to treat neuropathic pain with initial high irradiance/fluence rates for fast pain relief, followed by low irradiance/fluence rates for prolonged pain relief by altering chronic inflammation.
iEnovis
Pubmed
© 2022 Enovis Corporation
CONFIDENTIAL
Made with FlippingBook - PDF hosting