Chow 2016 | Analgesia
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Chow RT, Armati PJ. Photobiomodulation: Implications for Anesthesia and Pain Relief. Photomed Laser Surg. 2016 Dec;34(12):599-609.
Design & purpose : Review of electrophysiological studies in humans and animal models and cell culture studies to examine neural responses to PBM. Results : - Evidence shows that PBM can inhibit nerve function in vivo, in situ, ex vivo, and in culture. - Animal studies using noxious stimuli indicate nociceptor-specific inhibition with other studies providing direct evidence of local conduction block, leading to inhibited translation of pain centrally. - Evidence of PBM disrupted neuronal physiology affecting axonal flow, cytoskeleton organization, and decreased ATP is also presented. - PBM changes are reversible with no side effects or nerve damage.
KEY MESSAGE This review provides strong evidence in neuroscience identifying inhibition of neural function as a mechanism for the clinical application of PBM in pain and anesthesia.
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