NCUK Virtual Patient Handbook

FAQs - Genetics & Genomics

What biomarkers are commonly used in neuroendocrine canc Chromogranin A is the most widely used neuroendocrine cancer biom standard. It is used alongside other tests and scans - and is not recom Like many biomarkers it is not 100% accurate and may be influenced inflammatory disease / the use of PPIs (medicines that work by reduci 5-HIAA (5-hydroxyindoleacetic acid) is a by-product of serotonin and is 5-HIAA is usually one of the first biochemical marker checked when a support a carcinoid syndrome diagnosis. However, results may be alte impairment, certain medications / foods. The NETest® is a promising potential alternative to Chromogranin A, a required.

Komarnicki et al (2022) Circulating Neuroendocrine Tumor Biomarkers: Past, Present and Future. J Clin Med.;11(19):5542.

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Is genetic testing available on the NHS? Genetic testing is free on the NHS - if you are referred for it by a hosp You will generally only be referred if you have a suspected genetic hea It should be noted that current testing looks to identify known genetic m We need to understand the implications of a fault or fusion to determin decision-making, for such testing to be useful. Each of the 4 nations specialist testing services have a list which outlin NHS. For further information on genetic and genomic testing - visit the

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