NCUK Virtual Patient Handbook

Further information on these different types of therapy can be fou Current Targeted Molecular Medical Therapies that are used in neuroe include: • Everolimus (Afinitor) – which is a targeted drug that blocks mTOR, Everolimus may also stop tumours from developing new blood vess Everolimus is currently licensed (2023) within the UK to treat inopera tumours that start in the pancreas, gastrointestinal system or lung(s) a • Sunitinib (Sutent) is a targeted drug that works by stopping tumour blocking growth-stimulating proteins in the cancer cell itself. Sunitinib is currently licensed (2023) within the UK to treat inoperable tumours that start in the pancreas and show signs of ongoing growth / Clinical trials involving these and other anti-cancer medications are on What are the key difference between Chemotherapy and Targeted • Targeted therapies often block tumour cell proliferation (cytostasis), not have a specific molecular target, beyond cells that are rapidly di rapidly dividing cells. • In neuroendocrine cancer – chemotherapy is primarily used to treat Medical Therapies (as named here), are used only in neuroendocrin Immunotherapy uses our immune system to fight cancer, by helping types of immunotherapy are also called targeted treatments or biologic treatments.

Albertelli et al (2021) Present and future of immunotherapy in Neuroendocrine Tumors. Rev Endocr Metab Disord.;22(3):615-6

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