The physical presence of a cancer - it’s size, site and position Where a neuroendocrine cancer develops, it’s position and how big it is can affect what symptoms may develop. These symptoms include obstruction and/or pain.
Obstruction: Example 1: Lung Neuroendocrine Cancer
A cancer that starts to grow peripherally, that is, in a position away from the main structures, such as the bronchus, may not cause any symptoms - until (or unless) it grows larger or spreads elsewhere.
Whereas a cancer that starts to grow centrally, that is, in or near to the bronchus, can cause obstructive symptoms, such as a cough and/or wheeze.
Lung image adapted from Diagram 1: The Lungs, Neuroendocrine Cancer UK Lung Booklet p4. https://www.neuroendocrinecancer.org. uk/wp-content/uploads/2020/06/503906-LUNG-BOOKLET-v3.pdf
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