Octreotide (111 In(DTPA)-octreotide) scan - to diagnose and monitor neuroendocrine tumours. Tektroyd (99mTc-Tektrotyd) scan - similar to an Octreotide scan, but uses a different isotope. Gallium-68 DOTATATE (or Ga-68 DOTATATE)PET/CT - is also used to aid diagnosis and monitor neuroendocrine tumours. It is the ‘gold standard’ recommended scan for neuroendocrine tumours, due to its increased sensitivity and specificity. This means that it may be more useful in identifying smaller tumours and in the more accurate staging of receptor- positive disease distribution. Copper Cu 64 Dotatate PET Scan - not widely available may be an alternative to Gallium-Dotatate. Glucagon-like peptide-1 receptor (GLP-1R) PET scan - not widely available, but may be particularly helpful in detecting insulinomas. MiBG scan (iodine-123 meta-iodobenzylguanidine scan) - is used in certain types of neuroendocrine cancer that might be more sensitive to MiBG, such as pheochromocytoma and paragangliomas. FDG-PET scan (FluoroDeoxyGlucose Positron Emmission Tomography) - is more appropriate for high-grade neuroendocrine cancers - particularly NECs. NECs (and some high-grade NETs) do not have Octreotide receptors on their surface, and the cancer cells within them grow more rapidly than most NETs - burning up more energy. FDG is attracted to these areas of intense cell activity. Therefore FDG-PET is the preferred scan for identifying NECs (and some high-grade NETs).
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