Ellansé Patient Brochure

The secret to facial rejuvenation

1 ELLANSÉ BEAUTY GUIDE Model is not an actual patient.

Contents

4 Instant volume, long-lasting benefits. 6 The power of collagen 8 The ageing process

12 Results that last

13 What makes Ellansé 14 How Ellansé works

15 Safe and effective treatment 16 Why choose Ellansé? 18 My beauty with Ellansé 26 Frequently asked questions

10 More than traditional fillers

11 Areas of treatment

Model is not an actual patient.

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Instant volume, long-lasting benefits.

When it comes to enhancing your appearance, you don’t want a quick fix. You want a safe 1 way to rejuvenate your skin, one that can elevate who you are and provide results that last. That’s where we come in...

REBUILDING YOUR NATURAL BEAUTY What if we told you that you can get instant natural-looking results using your own collagen? That we hold the secret to a unique formulation that stimulates your body’s collagen to brighten your skin and improve its volume, firmness and elasticity? Through our extensive expertise and experience, we made it possible. We developed Ellansé® - the regenerative volumising filler. Where others’ benefits end at correcting lines and folds, Ellansé goes beyond, goes deeper, working to treat the true causes of facial ageing. While it instantly addresses lines and wrinkles, it also uses your body’s natural processes to set in motion long-term collagen production, safely restoring volume, rejuvenating your appearance from within. SAFELY NURTURING YOU BACK TO YOUR BEST Ellansé contains Polycaprolactone (PCL) microspheres – an effective and safe 1 component to use over long periods, closing the gap between surgical and non-invasive treatments. If you’re ready to enhance your appearance, together with your physician, you can unlock your natural beauty and your body’s amazing ability to volumise, rebuild and restore your skin.

Models are not actual patients.

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Collagen is a powerful, natural protein that exists within all of us. It contains elastin and hyaluronic acid which help keep our skin moist, and its elasticity strong. But did you know that your levels of collagen can start to decrease as early as in your twenties? This is when you’ll start to notice a difference in the firmness of your skin. A few lines and wrinkles appearing…

The good news is that you can take back control. With the help of Ellansé, you can reboot your body’s natural collagen production.

Model is not an actual patient.

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The ageing process

“ My skin looks youthful and I think my complexion as a whole just looks better, but not false in any way. ”

COLLAGEN IN YOUTHFUL SKIN

D

Collagen provides infrastructure for elastin and hyaluronic acid. Elastin helps the skin retain its elasticity. Water binds to hyaluronic acid keeping the skin moist. Well-structured collagen network.

A

E

F

B

C

COLLAGEN LOSS IN AGEING SKIN Decreased collagen , elastin and hyaluronic acid.

Skin ageing changes the shape of your face affecting various layers: Muscle tone and volume are lost. Fat is lost from the area. Bone is reabsorbed. Disorganised collagen network.

A Epidermis

Actual patient. Individual results may vary.

B Dermis

C Subcutaneous layer

D Collagen

E Elastin

F Hyaluronic Acid

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So much more than traditional fillers

Which areas can Ellansé treat?

A

UPPER-FACE

B

C

Our 2-in-1 action begins by correcting wrinkles and folds, then goes on to stimulate the body’s natural collagen production – resolving the underlying causes of facial ageing.

A. Forehead B. Temples C. Brow area

D

E

MID-FACE

By rebuilding and rejuvenating, layer by layer, Ellansé creates a firm foundation for lasting results.

D. Nose reshaping E. Cheek augmentation

F

1. IMMEDIATE action. • Fills wrinkles and folds. • Redefines shape and contours.

F. Nasolabial lines (the lines from your nose to the corners of your mouth)

1

G

2. LONG-TERM action through collagen stimulation. • Reverses the signs of ageing. • Rejuvenates face and provides a noticeable improvement in skin quality (density, firmness, elasticity, tonicity and texture). 2

LOWER-FACE

H

J

2

G. Corners of the mouth H. Marionette lines (the vertical lines that run down from the corners of your mouth) I. Chin J. Jawline

I

N

DID YOU KNOW? ELLANSÉ IS NOT JUST FOR LINES AND WRINKLES, IT CAN ALSO BE USED TO CONTOUR YOUR NOSE OR CHIN.

Model is not an actual patient.

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Results that last

What makes Ellansé?

Ellansé is available to all physicians in two formats. A collagen stimulator filler, Ellansé's results last longer than traditional fillers.

Model is not an actual patient.

A

B

S M ELLANSÉ 24 MONTHS * ELLANSÉ 18 MONTHS * In consultation, your physician will assess your skin and create a bespoke treatment plan, using the variant that best suits you.

A. MICROSPHERES Tiny sphere-shaped particles. B. CARRIER GEL The smooth microspheres are spread evenly throughout the gel.

* Treatment effects have variable duration dependant on the variant used, practitioner injection technique, patient lifestyle and metabolic rate.

Actual patient. Individual results may vary

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Ellansé works deep under the skin

The safe and effective treatment for skin rejuvenation 1

See how Ellansé's unique formula compares to other available treatments.

OTHER FILLERS †

ELLANSÉ®

RADIESSE®

SCULPTRA®

IMMEDIATE VOLUME RESTORATION (1-3 MONTHS)

YES

YES

NO

YES

BEFORE TREATMENT

STEP 1: IMMEDIATE RESTORATION OF VOLUME Ellansé contains smooth microspheres (tiny particles), evenly distributed in the carrier gel, which fill the areas of the skin affected by volume loss.

STEP 2: STIMULATION OF YOUR BODY’S NATURAL COLLAGEN PRODUCTION Over the course of a few months, the presence of smooth microspheres boosts your body’s natural collagen production. As the microspheres are broken down by the body, these collagen structures remain and continue to fill and provide volume to the skin.

LONG-TERM COLLAGEN STIMULATION

YES

NO

YES

NO

Depleted collagen, elastin and hyaluronic acid leading to lines, wrinkles and volume loss.

TREATMENT SESSIONS REQUIRED

1

1

3

1

>12 MONTHS

25 MONTHS **

12-18 MONTHS

18-24 MONTHS *

DURATION OF RESULTS

Ellansé helps to bring back your natural-looking beauty.

* Treatment effects have variable duration dependant on the variant used, practitioner injection technique, patient lifestyle and metabolic rate. ** Expected duration of action based on at least three sessions. Ellansé duration is based on one session only. † This is an overview of different long-lasting hyaluronic acid based fillers.

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Why choose Ellansé?

NATURAL-LOOKING, LONG-LASTING RESULTS

Ideal for both women and men.

More youthful contours and reshaping.

Immediate and noticeable correction of wrinkles and folds.

High clinical safety experience. 3

Facial rejuvenation by stimulating the body’s own defences. 2

Improves skin density, firmness, elasticity, tonicity and texture. 2

Results last from 18-24 months, depending on treatment.*

An established safety 1 profile to achieve optimal results. 3



*Treatment effects have variable duration dependant on the variant used, practitioner injection technique, patient lifestyle and metabolic rate.

HIGH PATIENT SATISFACTION 2

82%

90%

100%

78%

Model is not an actual patient.

of patients were satisfied with Ellansé 24 months after treatment. 3

of patients had improved , much improved or very much improved results at 12 months. 3

of patients had improved , much improved or very much improved results at 24 months. 3

of patients wanted to repeat Ellansé treatment in the future. 3

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MY BEAUTY WITH ELLANSÉ

“ I’d absolutely recommend Ellansé to family and friends, I have done already! It’s been fantastic. ”

BEFORE ELLANSÉ

2 WEEKS AFTER ELLANSÉ

Audrea AGE 45 2 WEEKS AFTER ELLANSÉ

Treatment volumes – Mid-face: 3.6 ml, Lower-face: 1.2 ml. The procedure featured was performed by Dr. Victoria Manning in London, UK, using Ellansé M. Actual patient. Individual results may vary.

BEFORE ELLANSÉ

2 WEEKS AFTER ELLANSÉ

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MY BEAUTY WITH ELLANSÉ

BEFORE ELLANSÉ

2 WEEKS AFTER ELLANSÉ

3 MONTHS AFTER ELLANSÉ

Cassie AGE 40 3 MONTHS AFTER ELLANSÉ

Treatment volumes – Mid-face: 2.7 ml, Lower-face: 1.2 ml. The procedure featured was performed by Dr. Victoria Manning in London, UK, using Ellansé M. Actual patient. Individual results may vary.

2 WEEKS AFTER ELLANSÉ

3 MONTHS AFTER ELLANSÉ

BEFORE ELLANSÉ

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MY BEAUTY WITH ELLANSÉ

BEFORE ELLANSÉ

2 WEEKS AFTER ELLANSÉ

3 MONTHS AFTER ELLANSÉ

Micheal AGE 57 3 MONTHS AFTER ELLANSÉ

Treatment volumes – Mid-face: 1.7 ml, Lower-face: 3.2 ml. The procedure featured was performed by Dr. Victoria Manning in London, UK, using Ellansé M. Actual patient. Individual results may vary.

BEFORE ELLANSÉ

2 WEEKS AFTER ELLANSÉ

3 MONTHS AFTER ELLANSÉ

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MY BEAUTY WITH ELLANSÉ

BEFORE ELLANSÉ

2 WEEKS AFTER ELLANSÉ

3 MONTHS AFTER ELLANSÉ

Paul AGE 48 3 MONTHS AFTER ELLANSÉ

Treatment volumes – Mid-face: 0.8 ml, Lower-face: 4.4 ml. The procedure featured was performed by Dr. Victoria Manning in London, UK, using Ellansé M. Actual patient. Individual results may vary.

BEFORE ELLANSÉ

2 WEEKS AFTER ELLANSÉ

3 MONTHS AFTER ELLANSÉ

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Frequently asked questions

Model is not an actual patient.

1. How long does a treatment take? A treatment takes approximately 30 minutes, depending on the areas treated.

4. Is the procedure painful? Tiny amounts of Ellansé are injected into the skin using an ultrafine needle, so any discomfort is minimal. It’s quick, simple, virtually painless, and gives instant results.

7. Is it OK to combine Ellansé with other aesthetic treatments? Ellansé should not be used in (or close to) sites where previous skin augmentation procedures have been applied. Please speak to your physician for more information. 8. What should I do following treatment? You’ll need to avoid hot bathing and vigorous exercise for 24 hours after treatment. Over-exposure to the sun and UV light should also be avoided for 1 week after treatment. 9. Are there any side effects? As with all fillers, there may be some swelling, localised redness at the injection site, itching and tenderness immediately after treatment. These are the result of the injection itself and generally resolve themselves. A full set of possible side effects is listed in the product’s ‘Instructions for Use’. For more information please consult your physician.

2. W hen will I see the effects of the treatment? Volumising effects and a reduction in wrinkles and folds can be seen

5. What is Ellansé made up of? Ellansé is composed of unique

immediately after treatment. Ellansé will then gradually stimulate the production of your body’s own collagen to treat the underlying causes of facial ageing for long-lasting and natural-looking results. 3. How long will the results last? Natural-looking and immediate results will last from 18 months,* depending on which Ellansé option your physician recommends for you. The results are maintained for the expected duration of effect according to the Ellansé option chosen, enabling you to avoid multiple sessions.

Polycaprolactone (PCL) microspheres and Carboxymethyl Cellulose (CMC) carrier gel, all naturally broken down by the body into carbon dioxide and water and then eliminated without leaving any traces in your body. 6. How many sessions are generally needed? With Ellansé, only one session is needed for immediate results and long-lasting correction, making Ellansé a cost-effective treatment that gives excellent value for money.

REFERENCES

1. Data on file. 2. Clinical study evaluating the effect of Ellansé on facial skin quality – Internal Report (2020). 3.Moers-Carpi, M. M., & Sherwood, S. (2013). Polycaprolactone for the correction of nasolabial folds: a 24-month, prospective, randomized, controlled clinical trial. Dermatologic surgery: official publication for American Society for Dermatologic Surgery [et al.], 39(3 Pt 1), 457–463. https://doi.org/10.1111/dsu.12054.

Model is not an actual patient.

*Treatment effects have variable duration dependant on the variant used, practitioner injection technique, patient lifestyle and metabolic rate.

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1st Floor Whitfield Court, 30-32 Whitfield St, London, W1T 2RQ, United Kingdom. E. ellanse@sinclair.com www.ellanse.com

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