Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood …

SF3B1 MT MDS-RS at the Single Cell Level

Ineffective erythropoiesis

Ringed Sideroblasts

SF3B1 MT

We profiled the hematopoietic landscape of SF3B1 MT MDS-RS at the single-cell level

Lin - CD34 + HSPCs

BM-MNCs

Ery

SF3B 1 MT Lin - CD34 + HSPCs:

Ery

 Increased Ery/Mk differentiation  Metabolic activation in SF3B1 -mutant cells

 Increased Erythroblast at the Orthochromatic stage SF3B 1 MT MNCs:

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