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"#0!S0*0Y2!'2%<4!8#$<&#))&!Q(%066!/%)j07(?!"#0!0::07(6!):!92(0%*2!Q>_!QB2%&$_!L>_!@2*$*$_!=>_!8)%&0%)_!@>_!Q2*7#)!5)66$D*)<_!=>_!S0cEL23%4_!>!>!>!5B67)*$!Q0%12_!Q>! [+,-]^>!H)Z!&)!92(0%*2$@+&;%<%B":$%+,C !! @)60%_!O>=>_!=B0_!">_!L2Y0C_!a>_!IB(<$M)Y2_!H>_!QB2%&$_!L>_!8)%&0%)_!@>;>_!5B67)*$_!Q>_!Q7#07#(0%_!O>Q>![+,-]!01B3! iB<4!+.^>!V$)<0*70E%0<2(0&!/"QO!2*&!*0B%2! 6"?)@BO& 8"L+),)<%O&@+*&/!!%?,)<%&0%>#"(?)%+?% >! Q7#07#(0%_!O>Q>_!@)60%_!O>=>_!50<$:)%&_!=>_!@782Z_!i>'>_!8)2(06_!Q>K>_!"B%*0%_!i>F>_!5B67)*$_!Q>_!K$<<#0$9_!'>![+,-.! 01B3!L03!+,^>!!a0D2($Y0!2*&!&$6()%(0&!2((%$3B($)*6!()Z2%&6!7#$<&_!60<:_!2*&!1%$92%4!2((27#90*(!:$DB%0_!29)*D! 1)6((%2B92($72<<4!6(%0660&!9)(#0%6?!!K#2(!7#2*D06!Z$(#!8<$*$72$@+&;%<%B":$%+, _!]g[-^_!-,E+,>! Q7#07#(0%_!O>Q>_!5B67)*$EQ0%12_!Q>![+,-]^>!R*&0%6(2*&$*D!#)Z!(%2B92($C0&!9)(#0%6!1%)7066!(#0$%!()&&<0%6m! 2::07($Y0!7)99B*$72($)*!B*&0%!6(%066?!")Z2%&6!1%0Y0*($Y0!$*(0%Y0*($)*!:)%!:29$<$06!2(!#$D#!%$6M!:)%! $*(0%D0*0%2($)*2!;*!'9&0!5_!@!G!A0BC$*D0%EF)#<030%!['&6^>!! 2@#BA&'@#%+,)+L&3%(%@#?-&@+*&'#%<%+,)"+& "!&;)("#*%#^&'(A?-"@+@BA,)?&&3%(%@#?-&@,&.+,%#*)(?):B)+@#A&Q#"+,)%#( ![11>!\,E--b^>!A)*&)*?!!I2%*27!F))M6>>! The Geneva Early Childhood Stress Project (GECS-Pro) Phase 1 was officially launched in 2010 at the Research Unit of the Child and Adolescent Psychiatry Service, Department of Pediatrics, University of Geneva Hospitals and Faculty of Medicine. The GECS-Pro is funded by the Swiss National Science Foundation as part of the National Center for Competence in Research on the Synaptic Bases of Mental Disorders (NCCR-SYNAPSY) as well as the Gertrude von Meissner, Prim’Enfance and the Oak Foundations. The GECS-Pro is a prospective longitudinal study that in Phase I (2010-2014) has included over 100 mothers of children ages 12-42 months. The study focus is to understand how maternal interpersonal violence exposure and related posttraumatic stress disorder (PTSD) affects the mother-child relationship particularly with respect to mutual affect regulation and the development of self-regulation of affect, arousal, and aggression in the child. The project examines psychological, behavioral physiologic, neuroimaging, and epigenetic data of both mother and children individually and in interaction in an effort to identify potential endophenotypic differences that contribute to the intergenerational transmission of violence and related psychopathology. A second focus of the GECS-Pro is to understand how child displays of negative affect, helplessness, and dysregulation impact the traumatically stressed parent, her mental representations of the child marked by her attributions to the child’s personality, and her caregiving behavior. Related to this second focus, we have further developed an experimental intervention technique the Clinician Assisted Videofeedback Exposure Session(s) or « CAVES » that had been developed as part of the principal investigators prior IPA-funded research in New York. This intervention is being further developed into a 12-16-session manualized brief psychotherapy the Clinician Assisted Videofeedback Exposure-Approach Therapy or « CAVEAT ». While the GECS- Pro Phase 1 will be ending recruitment in December, 2014, Phase 2 will be beginning in the spring, 2015 which will focus on longitudinal follow-up the children from Phase 1 at ages 5-9 years in an effort to identify individual differences with respect to aggressive versus anxious-depressed behaviors and symptoms. A second planned project within Phase 2 involves a controlled trial of the CAVEAT with a new cohort of 30 mothers and children ages 12-42 months.
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