MEDICATION KINETICS
Generic Name
T Cmax
Elimination t ½
Generic Name
T Cmax
Elimination t ½
ANTICHOLINERGICS
ANTACIDS Cimetidine (H 2 receptor
Biphasic:
PO: 60 min (45–90) IM:15 min
2 hrs Metabolites: 2.2 hrs
PO: 1 hour IM: 30 min
Atropine
Initial ~ 2 hr Second: 12.5–38 hr
antagonist) aka Tagamet
Glycopyrrolate aka Robinul Hyoscyamine
Famotidine (H 2 receptor antagonist) aka Pepcid
SC/IM: 10 min PO IR: 30 min PO ER: 2.5 hr
1 hr (0.55-1.25) 3.5 hrs DI ER:8-12 hrs
PO: 2 hrs (1–3.5)
3 hrs (2.5–3.5)
Enteric–coated granules: 2 hrs (1.5–3) ODT: 1.8–2.0 hrs
EM aka Levsin
< 2 hrs Metabolites: 3 hrs
Lansoprazole (PPI) aka Prevacid
PO: 1 hr SC: 30 min TD: 4 hr PO: 1-2 hrs IM: 30 min IV: 5 min
8 hrs (7-9) DI TD: 72 hrs
Scopolamine
DIURETICS Bumetanide aka Bumex Furosemide aka Lasix Metolazone
Omeprazole (PPI) aka Prilosec Pantoprazole (PPI) aka Protonix
PO: 2 hrs (0.5–3.5)
1 hr
60–90 min
PO: 2.5 hrs
1 hr
PO: 50 min(soln), 1.5 hrs (tab) IV: 6–10 min
2 hrs s
PO: 1 hr (0.5–2) IM: 15 min
Ranitidine (H 2 receptor antagonist) aka Zantac
2.5 hrs (2–3)
PO: 8 hrs
10 hrs (8–14)
Sucralfate aka Carafate
PO initial response: 1 hr Duration: 6 hrs
aka Zaroxolyn
1.5 hrs (1.3–2) Metabolite: 17 hrs (9 – 23)
Spironolactone aka Aldactone
aka = also known as IR = Immediate Release ER = Extended Release EM = Essential Medicine as defined by WHO and IAHPC SC dosing is preferable over IM dosing Avoid medications with short half-lives in patients with short life expectancy who may experience withdrawal when these medications are stopped at end of life.
PO: 2 hrs (1–3)
Torsemide
PO: 1 hr
4 hrs (3–6)
aka Demadex
68 NB: These Reference Cards do not replace careful clinical judgment specific to each patient / family situation. PCIC: Palliative Care Interdisciplinary Curriculum is a collaborative effort of OhioHealth, The Ohio State University Wexner Medical Center, and Nationwide Children’s Hospital in Columbus, Ohio, USA, and other contributors. Permission to reproduce any or all of these PCIC Reference Cards is granted for non-commercial educational purposes only, provided that the attribution statement and copyright are displayed. To reproduce for all other purposes, contact Frank D. Ferris at info@pallmed.us. Copyright © Frank D Ferris 2013-2024. All rights reserved. V14.1, 2024
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