MEDICATION KINETICS
Generic Name ANAESTHETICS Lidocaine
T Cmax
Elimination t ½
Generic Name
T Cmax
Elimination t ½
OTHERS Loperamide (antidiarrheal) aka Imodium Meperidine / Pethidine (rigors) aka Demerol
IM: 30 min
1.5–2 hr
PO: 4–5 hrs
10–12 hrs
Nitrous oxide
Rapid
5 min
3 hrs (3.2 – 3.7) Toxic metabolite 24-48 hrs
IM: 30 min
STIMULANTS Dextroamphetamine aka ProCentra
Metoclopramide EM
PO/PR: 1 hr (1–3) SC: 30 min IV: 15 min PO: 1–2 hrs PR: 3 hrs IV: end of infusion
PO: ~3 hrs
10 hrs (10-12)
(dopaminergic, prokinetic) aka Reglan
6 hrs (5–6)
Modafinil
PO: 2-4 hrs
15 hrs
Aka Provigil
Metronidazole
PO IR: 1–3 hrs PO ER: 1.5 – 7 (VARIES)
6–14 hrs
Methylphenidate aka Ritalin
3 hrs (2–7) DI ER: 24 hrs
aka Flagyl, MetroGel
Mexiletine (class 1B
OTHERS Baclofen
antiarrhythmic, neuropathic pain) aka Mexitil Misoprostol (prostaglandin E1 analogue) aka Cytotec
PO: 2.5 hrs (1-4)
12 hrs (6-17))
PO: 2 hrs
3 hrs (2.5-4)
Plasma:
Plasma: 15 min Max ↓ H + : 60-90 min
aka Lioresal
30 min (20-40)
Cyclizine
PO: 2 hrs
13 hrs (7–48)
aka Marezine, Cyclivert
Octreotide (somatostatin
SC: 15–30 min
1.5 hrs
Cyclobenzaprine aka Flexeril Diphenhydramine
analogue) aka Sandostatin
PO: 4 hrs
18 hrs (9–41)
Ondansetron EM (serotonin receptor antagonist) aka Zofran
PO: 1 hr (1–2.2) IM: 0.7 hr IV: 10 min after infusion ends
6 hrs (2–8) Metabolites: 8.6–10 hrs
6 hrs (3.1–5.8)
(H 1 receptor antagonist) aka Benadryl
PO: 2 hrs (2–4)
PO: 1hr TD Patch:17 hrs (10-28)
2.5 hrs (2-3) DI TD: 2x/wk 12 hrs (9–15)
Oxybutynin aka Ditropan
Flecainide (class 1C antiarrhythmic) aka Tambocor
PO: 3 hrs (1-6) PO cap: 1–8 hrs IV: 15 min
20 hrs (12-30)
Tamsulosin aka Flomax
PO: 4–5 hrs
aka = also known as IR = Immediate Release ER = Extended Release EM = Essential Medicine as defined by WHO and IAHPC
69 NB: These Reference Cards do not replace careful clinical judgment specific to each patient / family situation. PCIC: Palliative Care Interdisciplinary Curriculum is a collaborative effort of OhioHealth, The Ohio State University Wexner Medical Center, and Nationwide Children’s Hospital in Columbus, Ohio, USA, and other contributors. Permission to reproduce any or all of these PCIC Reference Cards is granted for non-commercial educational purposes only, provided that the attribution statement and copyright are displayed. To reproduce for all other purposes, contact Frank D. Ferris at info@pallmed.us. Copyright © Frank D Ferris 2013-2024. All rights reserved. V14.1, 2024
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