In addition to macrophages, fibroblasts, lymphocytes, plasma cells and eosinophils are involved in chronic inflammation. in tissue is characteristic of chronic inflammation. Fibroblasts secrete collagen, which form adhesions and scar tissue, causing loss of function in a tissue. The presence of
Lymphocytes secret chronic inflammation.
, which are an important chemical mediator in
cells have a useful role as they produce antibodies against any antigens present in tissue. In some autoimmune diseases, such as osteoarthritis, plasma cells produce antibodies against the body’s own tissues triggering a chronic inflammatory response. infestation. The presence of eosinophils in tissue or in blood is a strong indicator of either an allergic reaction or a parasite infestation. Eosinophils are seen in chronic inflammation related to allergies or
Granulomatous Inflammation
Granulomatous inflammation is a kind of chronic inflammation seen with some diseases. It is slow to develop but has a distinct pattern. A granuloma occurs in epithelial tissue when an antigen is ingested by a macrophage but not fully digested or destroyed. These macrophages, called cells, attract more macrophages to the site and re-phagocytize the antigen. The macrophages become surrounded by lymphocytes and plasma cells. Over time the granuloma is infiltrated by fibroblasts and giant cells and connective tissue is formed at the site of the granuloma trapping the leukocytes in the tissue. The now expanding foci of macrophages develops a necrotic centre
There are two major classes of granulomas, the first are
granulomas
and the second are granulomas. Foreign body granulomas are formed around an indigestible foreign body in tissue. Immune granulomas are triggered by the excessive or inappropriate production of antibodies. This type of granuloma is associated with some autoimmune diseases and hypersensitivity reactions.
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