Equine Pathology Workbook

3. Tissue

4. Organ

5. System

6. Body

In pathology response level is dependent on three factors:

1. The first is the of the pathogen. With a weak pathogen, response level tends to be lower while a strong pathogen elicits a higher response level.

2. Second, the of pathogen the body is exposed to has an effect on response level. With a small dose of pathogen lower response levels are usually sufficient while a large dose generally requires a higher response level.

3. The third factor governing response is the ability of the body’s to cope with a particular pathogen. Individuals in general good health, that have a balanced diet and are neither geriatric or very young have a stronger immune response than those who are already sick, undernourished, or are extremely old or young. Cellular Injury Healthy cells are dynamic and are constantly responding to stimuli in the external environment. This type of adaptation is a normal effort to maintain homeostasis. When a cells ability to adapt is exceeded, dysfunction and cellular injury occur. A stimulus that causes dysfunction is considered a . For example, a virus may take over the nucleus of a cell and alter the genetic material being replicated there, or the tearing of muscle fibres will prevent them from contracting.

The extent to which a particular pathogen can cause cell injury depends on the:

1. ________________________________________________________________________

2. ________________________________________________________________________

3. ________________________________________________________________________

4. ________________________________________________________________________

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