Stem Cell Joint Injections: Mechanisms of Action

Tendons connect muscle to bone and are built to withstand tensile (pulling) forces. But over time, repetitive use or trauma can cause microtears, thickening, and inflammation—a condition called tendinosis. Tendons

MSCs help by:

Stimulating tenocyte regeneration (cells that build tendon fibers)

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Realigning disorganized collagen fibers

Reversing chronic inflammation in the tendon sheath

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Improving elasticity and tensile strength

This leads to improved load transfer from muscle to bone and relief from conditions like rotator cuff tendinopathy, Achilles tendinosis, and elbow overuse syndromes.

Ligaments

Ligaments connect bone to bone and provide joint stability. When injured, they often heal with scar tissue or remain weak, increasing the risk of re-injury.

MSC therapy helps ligaments by:

Encouraging proper collagen synthesis and fiber alignment

Promoting fibroblast activation for strong tissue remodeling

Enhancing cross-linking of fibers to restore tensile capacity

Patients often notice greater stability and confidence in movement, especially after sprains or chronic laxity.

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