Vital Highlights 2014-2021

RESEARCH FELLOWSHI P

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Publications

Awards

Dr Yaser Hadi Gholami

To address this , we have developed a radiolabelled nanoparticle platform to : ( i ) detect metastatic disease with high sensitivity ( using PET / MR imaging modality ) in the lymph nodes ; ( ii ) provide sufficiently enhanced diagnostic quality image contrast in the lymph nodes to stage cancer ; ( iii ) treat metastases with a highly localised radiation dose that uses the natural immune system for targeting the lymph nodes ; and ( iv ) develop a sequential imaging , therapeutic and dosimetry protocol that can be utilized for future human clinical trials .

The aim of my project was to carry out the necessary preclinical animal studies in preparation for a first - in - human clinical study using our novel immuno - radio - nanomedicine platform in identifying and treating lymph node metastases . Metastases ( spread of cancer ) are the leading cause of death from all cancer types and first appear in tumour draining lymph nodes . For many patients , by the time the primary cancer is detected , it has already metastasised . This is further compounded by very limited and largely ineffective treatment strategies , resulting in poor prognosis . To date , an effective and safe method capable of exclusively targeting metastatic tumour cells that have spread to the lymph nodes or other organs does not exist .

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