Riley Children's Health Annual Report 2023 – 2024

Home to a high-volume, nationally ranked pediatric cardiology program, Riley Children’s Health delivers the full continuum of cardiac care from fetuses and premature infants to adults with congenital heart disease. Achieving exceptional patient outcomes, the Riley Heart Center has experienced significant growth in recent years. In addition to offering specialists in every clinical area of cardiology, we are active in research to address unmet needs in pediatric cardiology. CARDIOLOGY

RESEARCH HIGHLIGHTS

National Institutes of Health (NIH)-funded studies R01: Novel Molecular and Cardiac Imaging Paradigms for Precision Medicine in Aortopathy R21: An Integrated and Automated Tool for Quantification of Biomechanics in Fetal and Neonatal Echocardiography Larry W. Markham, MD , is a principal investigator of a $3.6 million NIH grant to improve the detection of heart disease in children with Duchenne muscular dystrophy. Investigators aim to integrate statistical modeling based on advanced imaging to improve the prediction of cardiomyopathy. Major study funded by the Additional Ventures Foundation Metabolic Profiles Identify Circulating Biomarkers Associated With Heart Failure in Young Single Ventricle Patients National program affiliations and accreditations ■ Pediatric cardiac catheterization and ECHO labs accredited by the Intersocietal Accreditation Commission ■ Member of the Cardiac Neurodevelopmental Outcome Collaborative ■ Accredited by the Adult Congenital Heart Association 42 research publications in 2023

DIVISION CHIEF Larry W. Markham, MD, FAAP, FACC Phillip Murray Professor of Pediatric Cardiology; Professor, Departments of Pediatrics and Medicine, IU School of Medicine > Connect with Dr. Markham on Doximity. >

PROGRAM DISTINCTIONS

Specialized programs Fetal Cardiology Program Partners in the Fetal Center, our cardiologists offer in-depth diagnostic imaging, evaluation and consultation during pregnancy to develop a

■ Ranked among the leading pediatric heart programs in the nation by U.S. News & World Report

26 board certified physicians

See full team member list

comprehensive treatment plan. Cardiovascular Genetics Program

■ National leader in patient outcomes with mortality rates below benchmark*

Fully integrated CV genetics program provides testing, evaluation and consultation for the full spectrum of heritable heart conditions: ■ Aortopathy ■ Cardiomyopathy ■ Inherited arrhythmia ■ Pulmonary hypertension ■ Familial lipid disorders ■ Congenital heart disease/syndromes > READ about genetic testing for newborns with congenital heart defects. Preventive Cardiology Program Cardiologists with expertise in preventive cardiology diagnose and manage both inherited and acquired dyslipidemia and pediatric hypertension (arrange for ambulatory blood pressure monitoring); provide lifestyle modification guidance in collaboration with a specially trained dietitian. Pediatric Cardiac Psychology Program New inpatient and outpatient program offers assessment and psychotherapeutic intervention for patients coping with acute or chronic heart conditions, procedures, and emergent events/trauma; assist adolescents in developing self-management skills in preparation for role as an adult patient.

NOTABLE PUBLICATIONS Journal of the American Heart Association: September 2023 A Multicenter Analysis of Abnormal Chromosomal Microarray Findings in Congenital Heart Disease Journal of the American College of Cardiology: April 2023 MEK Inhibition Improves Cardiomyopathy in Costello Syndrome Journal of the American College of Cardiology: March 2023 Risk of Sudden Death in Patients With RASopathy Hypertrophic Cardiomyopathy Pediatric Cardiology: January 2023 Impact of Home Monitoring Program and Early Gastrostomy Tube on Interstage Outcomes Following Stage 1 Norwood Palliation American Heart Journal: April 2023 Design of a Multi-Institutional Neurocognitive Discovery Study in Adult Congenital Heart Disease (MINDS-ACHD) Digestive and Liver Disease: January 2024 Biomarkers of Fibrosis and Portal Hypertension of Fontan-Associated Liver Disease in Children and Adults

■ Integrated care model with subspecialty care coordination and novel approaches to cardiac intensive care, inpatient navigation and home monitoring ■ Only formalized comprehensive adult congenital heart disease program in Indiana; program accredited by the Adult Congenital Heart Association

Echocardiogram Interpretations: 2019 – 2023 Our program serves more than 40 Indiana hospitals and achieves record volume.

Fetal Echocardiogram Volume: 2019 – 2023

Performed at eight locations across Indiana

24,371

22,726

2,764

21,177

2,569

2,307

17,938 17,887

1,927

1,670

2019

2020

2021

2022

2023

2019

2020

2021

2022

2023

* Source: Society of Thoracic Surgeons (STS) Table 16, Harvest Report, published January 2024 for period ending June 30, 2023

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Annual Report 2023 – 2024

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