The Ryan White Center for Pediatric Infectious Diseases and Global Health at Riley Children’s Health helps children and families affected by infectious diseases overcome or manage these conditions. In addition to prevention and diagnosis, specialists at Riley Children’s focus on treatment and ongoing care of children with these conditions. The center offers services designed to provide complete care for children with infectious diseases, including prevention of infection and its complications. In 2023, our team facilitated more than 6,500 inpatient and outpatient visits. INFECTIOUS DISEASES
RESEARCH HIGHLIGHTS
40 funded research projects in 2023
23 funded by the National Institutes of Health
15 newly funded
Major international research studies ■ SMART Brain: Severe Malaria and Risk to the Brain ■ BRAIN-Child: Biomarkers and risk of acute brain injury and neurodisability in children ■ MAP-CKD: Investigating malaria-associated pathogenesis of chronic kidney disease ■ ABC: Acute brain injury and blood-brain barrier dysfunction in cerebral malaria ■ Gut microbiota and human malaria ■ Assessing risk of adolescent disengagement with HIV care ■ Predicting neurodevelopmental risk in children born to mothers living with HIV in Kenya ■ Developing a Mentor Mother strategy for improving mother- infant HIV outcomes in western Kenya Clinical research studies based at Riley Children’s ■ PFAPA: Understanding genetics and immunology ■ Short versus standard course anti-fungal therapy for uncomplicated candidemia ■ Noninvasive blood testing to detect invasive pulmonary mold infections ■ Member of Overcoming COVID-19 Research Consortium and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
DIVISION CHIEF Chandy C. John, MD, MS Ryan White Professor of Pediatrics, IU School of Medicine > Connect with Dr. John on Doximity.
PROGRAM DISTINCTIONS
Specialized programs Immunocompromised Host Infectious Diseases Consult Service Inpatient and outpatient services range from pretransplant evaluations to treatment of opportunistic infections in children with primary or acquired immune deficiencies. HIV Program An expert, globally engaged team provides comprehensive care to more than 80 children and adolescents receiving highly active antiretroviral therapy. International Travel Program We offer health services before and after international travel, including preventive medicine, vaccinations, education and support for parents of internationally adopted children. Infection Prevention Program Multidisciplinary team strives not only to treat infection, but also to prevent it through vaccinations, evidence-based prevention measures and education. Antimicrobial Stewardship Program We work to ensure the appropriate use of antibiotics and develop clinical practice
13 board certified physicians
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■ Among the largest pediatric infectious diseases programs in the Midwest ■ International leader in pediatric infectious diseases and global health research and clinical care ■ Nationally recognized specialty care of children with HIV, infections in immunocompromised children and pediatric travel medicine
See full team member list
■ Internationally recognized for pediatric malaria and HIV research
NOTABLE PUBLICATIONS Neurology: August 2023
■ One of 13 children’s hospitals designated by the Infectious Diseases Society of America as an Antimicrobial Stewardship Center of Excellence
The Journal of Adolescent Health: March 2023 Caring for Adolescents and Young Adults With Tuberculosis or at Risk of Tuberculosis: Consensus Statement From an International Expert Panel Clinical Infectious Diseases: February 2023 BNT162b2 mRNA Vaccination Against Coronavirus Disease 2019 Is Associated With a Decreased Likelihood of Multisystem Inflammatory Syndrome in Children Aged 5 – 18 Years–United
Admission Clinical and EEG Features Associated With Mortality and Long-term Neurologic and Cognitive Outcomes in Pediatric Cerebral Malaria Clinical Infectious Diseases: February 2023 Effect of Malaria and Malaria Chemoprevention Regimens in Pregnancy and Childhood on Neurodevelopmental and Behavioral Outcomes in Children at 12, 24 and 36 Months: A Randomized Clinical Trial Pediatrics: April 2023 Severe Malaria and Academic Achievement Nature Communications: October 2023 Gut Bacteroides Act in a Microbial Consortium to Cause Susceptibility to Severe Malaria
Our team is a leader in advanced rapid detection of antibiotic-resistant bacteria.
guidelines to combat the global threat of antibiotic- resistant organisms, while improving patient outcomes and healthcare costs.
VIDEO SERIES
Watch how infectious diseases have evolved over the past 100 years and what Riley Children’s is doing today to make a difference for kids in Indiana and around the globe.
States, July 2021 – April 2022 Pediatrics: November 2023 Epidemiology and Severity of Illness of MIS-C and Kawasaki Disease During the COVID-19 Pandemic
85 research publications in 2023
Outpatient Parenteral Antimicrobial Therapy Team Our team of physicians, pharmacists and nurses works closely with families, enabling them to receive intravenous antibiotics at home.
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Annual Report 2023 – 2024
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