Riley Children's Health Annual Report 2023 – 2024

Pulmonology and sleep medicine specialists at Riley Children’s Health provide advanced, child-focused and family-centered clinical care to children with respiratory and sleep disorders. Our team serves as a specialized medical home that works together with hospital and community-based providers to treat children with chronic respiratory illnesses. PULMONOLOGY AND SLEEP MEDICINE RANKED 7 TH IN THE NATION

RESEARCH HIGHLIGHTS

Riley Pulmonology Clinical Trials Volume: 2020 – 2023

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DIVISION CHIEF James F. Chmiel, MD, MPH, ATSF Professor of Pediatrics, IU School of Medicine > Connect with Dr. Chmiel on Doximity.

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PROGRAM DISTINCTIONS

Specialized programs ■ Aerodigestive Program ■ Bronchopulmonary Dysplasia Program ■ Cystic Fibrosis Program ■ Interstitial Lung Disease Program ■ Neuromuscular Program ■ High-Risk Asthma Program ■ PCD Program Advanced technologies and procedures Sleep medicine ■ Diagnostic neonatal and infant polysomnograms ■ O2 and PAP titration polysomnograms Pulmonary hypertension ■ Home monitoring using iPad Cystic fibrosis ■ Theratyping Aerodigestive disorders ■ EndoFLIP ■ Transnasal endoscopy Pulmonary function testing ■ Infant pulmonary function testing, including DLCO National recognition James F. Chmiel, MD, MPH, ATSF: American Thoracic Society Public Advisory Roundtable William J. Martin II Distinguished Achievement Award Benjamin M. Gaston, MD: Association of American Physicians

Select pulmonology research studies Funded by the National Institutes of Health ■ Scientific Innovation for Personalized Severe Asthma Management (P01 grant) ■ Clinical Trial to Evaluate Pharmacokinetics and Safety of Slow Release DHEA (Phase IIa) ■ Healthy Lungs Two (HL2): Respiratory Outcomes of Full Term Infants with Healthy Lungs ■ Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function ■ PARK: Preventing Asthma in High Risk Kids ■ PrecISE: Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network ■ Obesity and Childhood Asthma: The Role of Adipose Tissue Funded by the Cystic Fibrosis Foundation ■ HERO-2: Home-Reported Outcomes in People with Cystic Fibrosis Taking Highly Effective CFTR Modulator Therapy ■ Targeting ER Luminal ER-QC to Rescue Mutant CFTR

■ Seventh leading pediatric pulmonology program in the nation as ranked by U.S. News & World Report ■ One of the largest cystic fibrosis programs in the nation; only program in Indiana accredited by the Cystic Fibrosis Foundation

22 board certified physicians

See full team member list >

JAMA Pediatrics: January 2023 Effect of Vitamin C Supplementation for Pregnant Smokers on Offspring Airway Function and Wheeze at Age 5 Years: Follow-Up of a Randomized Clinical Trial Annals of the American Thoracic Society: November 2023 The Impact of SARS-CoV-2 Infection on Symptom Control and Lung Function in Children with Asthma Sleep Health: February 2023 Racial Disparities in the Pharmacological Treatment of Insomnia: A Time-to-Event Analysis Using Real-World Data Journal of Cystic Fibrosis: November 2023 Nasal Airway Inflammatory Responses and Pathogen Detection in Infants With Cystic Fibrosis Journal of Cystic Fibrosis: February 2023 Re-Examining Baseline Lung Function Recovery Following IV-Treated Pulmonary Exacerbations Pediatric Pulmonology: July 2023 The U.S. National Registry for Childhood Interstitial and Diffuse Lung Disease: Report of Study Design and Initial Enrollment Cohort NOTABLE PUBLICATIONS

■ Home to the nation’s only multidisciplinary program for patients with Alström syndrome

■ One of nine pediatric centers in the nation to be accredited as a Pulmonary Hypertension Center of Comprehensive Care

A leader in primary ciliary dyskinesia (PCD) Our team has developed advanced capabilities for performing both high-speed video microscopy (HSVM) and immunofluorescence microscopy (IFM) to diagnose PCD. We are using these advanced diagnostic tools as part of a leading- edge research program in the U.S. to clinically validate other methods for diagnosing PCD.

PCD Patient Volume: 2020 – 2023 67 81

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> READ more about HSVM and IFM at Riley Children’s.

Cystic Fibrosis Patient Volume: 2020 – 2023 328 360

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Program accreditations ■ Cystic Fibrosis Foundation

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Aerodigestive Program Patient Visits: 2020 – 2023 234 332 383

■ American Academy of Sleep Medicine ■ Primary Ciliary Dyskinesia Foundation ■ Therapeutics Development Network

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Annual Report 2023 – 2024

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