Riley Children's Health Annual Report – October 2026

RESEARCH HIGHLIGHT

Physician-scientists and researchers at Riley Children’s Health are bringing leading-edge treatments to the bedside. Their ingenuity and forward-thinking approaches are supported by the Herman B Wells Center for Pediatric Research and the Indiana University School of Medicine Department of Pediatrics , ranked No. 6 in National Institutes of Health funding. INNOVATORS

Groundbreaking research is underway at Riley Children’s, including:

DIABETES & ENDOCRINOLOGY Riley Children’s is leading TADPOL – a novel clinical trial investigating a disease-modifying therapy for Type 1 diabetes. NEPHROLOGY Riley nephrologists have uncovered new findings about kidney damage in children with vesicoureteral reflux. PULMONOLOGY Physician-scientists at Riley Children’s have shown efficacy of cystic fibrosis transmembrane conductance regulator modulators in patients without a qualifying mutation.

NEONATOLOGY Using rapid genome sequencing to detect genetic disease in infants in the neonatal intensive care unit (NICU), specialists have developed a genetic evaluation algorithm, creating a paradigm shift in clinical practice across Riley NICUs. GASTROENTEROLOGY To understand the biology of pediatric metabolic dysfunction-associated steatohepatitis, a Riley gastroenterologist is developing bioengineered liver organoids , mini models of pediatric liver disease, using innovative technology developed by a research partner at Purdue University.

> READ about these innovations and other current research at Riley Children’s.

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