Riley Children's Health Annual Report – October 2026

UROLOGY The fellowship-trained urology surgeons at Riley Children’s Health are internationally recognized for their expertise in treating complex urologic conditions. Skilled in open, endoscopic and robotic urologic surgery, our surgeons are partners in multidisciplinary programs to

Professional organization affiliations PRESIDENT

RESEARCH HIGHLIGHTS

RANKED 4 th IN THE NATION

Transitional urology and spina bifida outcomes Investigators reported new findings on the impact of urinary and fecal incontinence on quality of life in adults with spina bifida. Optimizing care for complex bladder conditions Our researchers examined reconstructive strategies aimed at preserving bladder and kidney function in patients with congenital anomalies, helping to guide surgical decision-making and counseling for families. Evidence to improve clinical decision-making Our physicians published a systematic review and meta-analysis examining voiding dysfunction after ureterocele treatment, providing the most comprehensive assessment to date of this important complication. Additional work explored the role of artificial intelligence and large language models in pediatric urology.

American Board of Urology > Mark P. Cain, MD, FAAP PRESIDENT Societies for Pediatric Urology > Rosalia Misseri, MD, FAAP, FACS EDITORIAL BOARD MEMBER Central European Journal of Oncology > Konrad M. Szymanski, MD SENIOR EDITOR Journal of Pediatric Urology > Rosalia Misseri, MD, FAAP, FACS

aid in managing multifaceted patient needs. We use data-based performance metrics to continuously improve quality of care and to assist in elevating quality of life for patients with challenging conditions.

Premier programs

Advanced technologies and procedures ■ Minimally invasive and robotic surgery ■ Mini-percutaneous nephrostolithotomy ■ Sacral neuromodulation therapy ■ SPY fluorescence imaging technology ■ In-office therapy for neuropathic bladder, including onabotulinum toxin, stone removal and bulking agents (allowing patients to have procedures in a comfortable, supportive environment without anesthesia) ■ Videourodynamic evaluation

TOP DISTINCTIONS

Riley Children’s is the only facility in Indiana and one of the few in the Midwest to offer programs for: Anorectal malformations Multidisciplinary care partners: Riley pediatric surgeons and gastroenterologists Congenital anomalies of kidney and urinary tract Multidisciplinary care partners: Riley nephrologists, psychologists and medical geneticists Urinary tract stones Multidisciplinary care partners: Riley nephrologists and dedicated program dietitian

■ One of the largest-volume centers for pediatric robotic urologic surgeries in the U.S. ■ Among the U.S. centers with the highest volume of complex reconstructive urologic surgeries ■ One of nine Congenital Adrenal Hyperplasia (CAH) Comprehensive Care Centers in the U.S. (designated by the CARES Foundation ) ■ One of 10 bladder exstrophy centers of excellence in the nation (designated by the Association for the Bladder Exstrophy Community )

LEADER IN TRANSITIONAL UROLOGY RESEARCH

Our urologists are at the forefront of research focused on patients living with congenital urologic conditions. These studies help define how urinary and bowel symptoms affect quality of life, informing patient-centered approaches to care and supporting the development of dedicated transition programs that improve outcomes.

NOTABLE PUBLICATIONS

The Journal of Urology: October 2025 Evaluating decisional regret in adults with spina bifida regarding childhood surgeries for neurogenic bladder and bowel Study provides long-term patient-reported outcomes, highlighting how childhood surgical decisions impact adult satisfaction and quality of life. It directly informs shared decision-making and counseling for families considering complex reconstructive interventions. The Journal of Urology: March 2025 Use and disuse of catheterizable channels as the primary method of emptying the neuropathic bladder: A single institutional cohort study Study examines real-world utilization and durability of catheterizable channels, offering valuable insight into long-term success and patient adherence. Findings help guide surgical planning and set realistic expectations for patients and families. Journal of Pediatric Urology: April 2025 Day-to-day variations and effects of urinary and fecal incontinence among adults with spina bifida: An ecological momentary assessment diary pilot study Using innovative real-time data capture, this study reveals the daily burden and variability of incontinence in adults with spina bifida. It advances how outcomes are measured and supports more patient-centered approaches to symptom management.

Urology Volume: 2025

Outpatient visits 22,000 Unique outpatients 18,000

The Riley Transitional Urology Program, one of the few programs of its kind in the U.S., prepares pediatric patients to transition into adulthood. The program delivers care to patients 18 and older who are navigating their congenital urologic health conditions as adults.

Surgical cases 4,800

Excellence in training and education ■ The pediatric urology fellowship at Riley Children’s and IU School of Medicine has been training leaders in urology for more than 30 years and is one of the longest-running pediatric urology fellowships in the nation. ■ Our team hosts observerships for pediatric urologists from around the world. ■ Riley Children’s is home to the first postgraduate training program for nurse practitioners specializing in pediatric urology.

DIVISION CHIEF Rosalia Misseri, MD, FAAP, FACS Robert A. Garrett Professor of Pediatric Urological Research, IU School of Medicine > Connect with Dr. Misseri on Doximity.

10 board certified/board eligible physicians

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