RESEARCH HIGHLIGHTS
MATERNITY & NEWBORN HEALTH
NEONATOLOGY
PLaNT – Multicenter international clinical study to compare the use of early prophylactic CPAP with no CPAP among late preterm newborn infants born via cesarean SUGAR – Implementation-effectiveness trial promoting the evidence-based practice of early supraglottic airway rescue during neonatal resuscitation on implementation outcomes OptiSTART – Study to determine whether targeting Sat75 compared to Sat50 increases survival without BPD STAR – Study evaluating the safety, tolerability, pharmacokinetics and preliminary efficacy of investigational drug RLS-0071 in newborns with moderate or severe hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia NAVEG – Study to evaluate use of the Neonatal Assessment Vision European Grid (NAVEG) test as a tool for early identification of cerebral/cortical vision impairment in at-risk infants
Riley Children’s Health provides advanced, evidence-based care for premature and critically ill newborns. We partner with families and referring providers from prenatal consultation through NICU care, discharge and follow-up, ensuring seamless, coordinated care at every stage. Home to a Level IV NICU, Riley Children’s offers the highest level of neonatal expertise and serves as a trusted resource for the region’s most complex patients.
Advanced technologies and procedures ■ Rapid whole genome sequencing ■ Neonatal continuous renal replacement therapy ■ Point-of-care ultrasound ■ ECMO program designated as a Platinum Level Center of Excellence by the Extracorporeal Life Support Organization ■ Miris human milk analyzer measuring nutritional content in breast milk ■ NicView cameras live streaming video of hospitalized infants to families through password-protected system
Premier programs
TOP DISTINCTIONS
Bronchopulmonary Dysplasia (BPD) Program Expertise in caring for extremely premature infants at highest risk for chronic lung disease. Our multidisciplinary team provides specialized care from the Small Baby Unit through outpatient follow-up, working to reduce the severity of BPD and other prematurity-related complications while improving long-term lung health, growth and developmental outcomes. NeuroNICU Program Delivering specialized care for newborns with serious neurologic conditions, this program combines advanced monitoring, evidence-based therapies and targeted surveillance to optimize brain development and improve outcomes. Launched in 2021 to advance precision medicine in the NICU, our Perinatal Genomics Program has been the subject of seven scientific presentations at national conferences. Program experts also hosted a two-part Approaches to Using Rapid Genome Sequencing in Your NICU webinar.
Transition to Home Initiatives ■ NICU Twistle Program -- Automated digital workflows and real-time communication keep families connected, informed and engaged, improving care coordination and ensuring a safer, more confident transition from hospital to home. ■ Early Years Program -- Provides dedicated follow-up care for NICU graduates to improve long-term outcomes. ■ Neonatal Telemedicine Program -- Delivers remote monitoring and support for more than 500 Indiana families annually, helping infants thrive closer to home. Leader in quality and safety outcomes Central line-associated bloodstream infection (CLABSI) rates <0.38 per 1,000 line days Standardized infection ratio <0.23 well below national benchmarks
■ Expert Perinatal Genomics Program advancing precision medicine in the NICU through expert genetic evaluation, rapid diagnosis and personalized care for newborns with complex medical needs; 100% of NICU patients screened for genetic disease risk ■ Nationally recognized expertise in neonatal kidney health; Riley specialists lead international collaborative networks that shape kidney care standards and advance innovative renal therapies for newborns and infants ■ Highly specialized, integrated care model in which neonatologists, cardiovascular intensivists and cardiologists partner in daily multidisciplinary rounds to deliver seamless, coordinated care for newborns with complex congenital heart disease; model found in fewer than 10% of centers nationwide * ■ Level IV NICU consistently recognized in the top 10% of high-acuity NICUs nationwide – Cares for one of the highest-acuity neonatal populations among participating NICUs ** – Achieves excellent outcomes despite ranking among the nation’s highest- volume centers for newborns with significant medical complexity ***
74 research publications in 2025
NOTABLE PUBLICATIONS
Pediatrics: July 2025 Standardized criteria for genomic testing in the NICU Journal of the American Heart Association: May 2025 Role of maternal obesity in offspring cardiovascular development and congenital heart defects Journal of Perinatology: January 2025 Decreasing early invasive mechanical ventilation exposure in
preterm infants: A quality improvement initiative American Journal of Perinatology: May 2026
The effect of continuous neuromuscular blockade in a cohort of patients with evolving or grade 3 bronchopulmonary dysplasia Pediatric Research: November 2025 Deciphering epigenetic control of Notch signaling in persistent pulmonary hypertension of the newborn
Quality and safety ■ With a 98% postoperative euthermia rate, our team consistently delivers the highest standards of surgical safety and temperature management for newborns undergoing surgery. ■ Approximately 75% of infants discharged from Riley NICUs are on breastmilk. ■ For neonate growth at discharge, Riley NICUs continue to rank within the top quartile of Vermont Oxford Network centers.
RILEY NEONATOLOGY: BY THE NUMBERS Volume Nearly 1,500 neonates receive care at Riley Children’s each year.
DIVISION CHIEF Laura S. Haneline, MD Edwin L. Gresham Professor of Pediatrics, IU School of Medicine > Connect with Dr. Haneline on Doximity.
63 board certified physicians
See full team member list >
Unplanned extubation rate 0.18 per 100 ventilator days
* Children’s Hospitals Neonatal Consortium (CHNC) survey of 25 centers that care for neonates with congenital heart disease ** Children’s Hospitals Neonatal Consortium (CHNC) (2025). Children’s Hospitals Neonatal Database *** Children’s Hospital Association (2025). Pediatric Health Information System
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