2) Proper circulation is necessary to transport oxygen, nutrients, antibodies, and many defense cells to the injured site. Circulation is also necessary for the removal of waste. 3) Age is the third factor in tissue repair. Generally, the younger we are, the better our tissues heal. This is generally due to a better nutritional state, better circulation, and higher rate of metabolic rate. Also, as tissue ages, glucose is added to proteins inside and outside of the cell. This forms irreversible cross links between adjacent protein molecules. With more age, comes more cross links contributing to a stiffening and loss of
elasticity.
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