Longevity Medical Institute FAQ's

Longevity Medical Institute MX believes that an informed patient is an empowered patient. That’s why we’ve developed an extensive FAQ section as a cornerstone of our commitment to education and transparency.

Knowledge Center

Empowering Patients Through Education and Transparency At Longevity Medical Institute, we believe that an informed patient is an empowered patient. That’s why we’ve developed an extensive FAQ section as a cornerstone of our commitment to education and transparency. Our FAQ is designed to address common questions, clarify complex topics, and provide comprehensive insights into our innovative treatments, diagnostic technologies, and personalized care protocols. From understanding the science behind stem cell therapies and hyperbaric oxygen therapy to navigating the details of anti-aging and wellness treatments, our FAQ ensures that patients feel confident and well-informed every step of the way.

Transparency is integral to the patient journey at LMI. By openly sharing the "why" and "how" of our cutting-edge approaches, we foster trust and build a collaborative partnership with each individual. Our FAQ is not just a resource—it's a reflection of our dedication to ensuring that every patient feels supported, educated, and fully engaged in their transformative health journey. Stem Cells FAQs What Are Stem Cells and How Do They Support Regenerative Medicine? Stem cells are special, undifferentiated cells that have the unique ability to transform into various specialized cell types within the body. They play a vital role in growth, anti- inflammatory, immune regulation, tissue repair, and maintaining overall health, making them essential for regenerative medicine. Different types of stem cells are used for different medical purposes, so treatments are carefully tailored to meet specific needs - it's not a one-size-fits-all approach at LMI. What Types of Stem Cells are used in LMI Treatments? At Longevity Medical Institute (LMI), we use four (4) types of ethically sourced multi-potent stem cells, including: • Wharton's Jelly-derived Stem Cells (WJ-MSCs): Found in the umbilical cord, WJ- MSCs are highly versatile cells that can be used in treatments for immune disorders, neurological conditions, and overall regeneration. • Placenta-derived Stem Cells (P-MSCs): These cells are known for their powerful regenerative and immunomodulatory effects, ideal for tissue repair and anti- inflammatory treatments. • Endometrial Stem Cells (eMSCs): These endometrium- derived cells are particularly effective in reproductive health and gynecological applications but can also promote blood vessel growth in other tissue types. • Adipose-derived Stem Cells (adMSCs): These are derived from fat tissue and are highly effective for cosmetic and musculoskeletal applications due to their ability to regenerate soft tissue and reduce inflammation. Why Does Longevity Medical Institute use Different Types of Stem Cells for Treatment? We believe that each patient and condition is unique, which is why we use multiple types of stem cells tailored to the specific therapeutic needs. Stem cells are more effective when applied to their tissue of origin because they naturally respond to the local signals like growth factors and cytokines, promoting faster healing and regeneration. Their lineage preference makes them more likely to differentiate into the specific cell types needed for that tissue, ensuring more efficient integration and improved outcomes.

Why Not Just Use One Type of Stem Cell for All Treatments Like Other Stem Cell Clinics Do? While all stem cells share regenerative properties, their tissue source of origin influences how they behave and what conditions they are most effective at treating. For example, some stem cells are more naturally suited for reducing inflammation, while others are better at promoting tissue repair or addressing specific types of conditions. These differences allow for a more targeted approach to therapy. Our doctors carefully evaluate each patient’s unique medical needs and use the latest research to determine the most appropriate stem cell type or combination for optimal results. By tailoring treatments based on these factors, we can maximize the therapeutic potential and deliver better outcomes for a wide range of conditions. Can using Multiple Stem Cells Improve Outcomes? Yes, using the right type of stem cell for the specific condition can significantly enhance outcomes. For example, WJ-MSCs and P-MSCs have potent anti-inflammatory and regenerative effects ideal for systemic conditions, adMSCs are perfect for tissue-specific needs like collagen and fat tissue, and eMSCs are highly effective for gynecological applications, such as treating uterine damage or promoting reproductive health. By matching the stem cell type to the condition, we ensure more targeted healing, better honing and signaling, and faster recovery. How do you decide which type of stem cell to use for a patient? Our decision is based on a thorough diagnostic process. Once we assess the patient's condition, medical history, and therapeutic goals, our team of experts determines which type of stem cell (or combination of cells) will provide the most effective treatment. Whether it's for joint repair, cosmetic enhancements, or systemic conditions, we select the type of stem cell best suited to achieve optimal results. Can multiple types of stem cells be used in a single treatment? In certain cases, we may use multiple types of stem cells to address complex or multi- system conditions. For example, a patient might receive P-MSCs for joint and muscle repair along with WJ-MSCs to reduce inflammation and promote overall healing. By combining stem cell types, we can provide a more comprehensive approach to treatment. Are Any Babies or Embryos Harmed When You Derive Stem Cells That Are Used at LMI? No babies or embryos are harmed in the process of deriving stem cells used at Longevity Medical Institute. The stem cells are ethically sourced from donated umbilical cord tissue, placenta, and cord blood after a healthy, full-term birth. These donations are voluntary and occur with informed consent from the parents. The process does not involve the use of embryos or any harm to the baby or mother, as the tissue is collected from material typically discarded after childbirth. Additionally, all stem cells are carefully screened to rule out the

transfer of any diseases. This process allows us to provide regenerative treatments without ethical concerns. Should I bank my baby’s umbilical cord in a cell bank? Banking umbilical cord blood and tissue may seem like a valuable investment for potential future medical needs. However, the practice can be very expensive and has significant limitations. Stored cells often require specialized processing in a lab to make them usable for therapies, which adds complexity and cost. Moreover, stored cells might not be suitable for certain therapies or may lose functionality over time. Donor cells, on the other hand, are readily available and can offer similar or superior benefits without the need for costly storage or processing. What does "immunologically privileged" mean for donor cells? Immunologically privileged cells, like mesenchymal stem cells (MSCs), can often be used without triggering an immune response. This unique property allows them to be applied in therapies across different individuals without requiring a genetic match, making donor cells a practical and versatile option. Why are donor cells often more effective than autologous cells? Donor cells, especially those from young, healthy individuals, tend to have stronger regenerative properties. They proliferate more effectively, communicate better with surrounding tissues, and promote healing and repair more efficiently. In contrast, autologous cells - particularly from older individuals - may have reduced regenerative capacity due to the natural aging process or health-related factors. What are the benefits of using donor cells (allogenic) over using your own cells (autologous)? Donor cells offer enhanced regenerative potential and greater adaptability, as they are not subject to the age-related decline or health issues that can affect autologous cells. They are also readily available and do not require the time, cost, or effort involved in harvesting and processing one’s own cells. This makes donor cells a convenient, cost-effective, and often superior option for regenerative therapies. Is banking umbilical cord cells ever necessary? While cord banking can provide a sense of security, it is not essential in most cases. The limitations of stored cells and the availability of robust, high-quality donor cells make banking less critical for many families. Unless there is a specific medical reason or family history that supports banking, donor cells often serve as an equally effective and more practical alternative for regenerative medicine. What is the difference between using your own cells (autologous) and donor cells (allogeneic)? Autologous stem cells are derived from your own body, typically from sources like bone marrow, fat tissue, or blood. These cells are reintroduced to support healing and regeneration and are highly biocompatible since they come from your own body.

Allogeneic stem cells, on the other hand, are sourced from younger, healthy donors. These cells are typically more effective because they have not undergone the cellular degradation associated with aging, making them more potent for regenerative purposes. What are the benefits of using donor cells, and why are your own cells sometimes less effective? Donor cells, especially those sourced from younger, healthy individuals, are more robust and effective for regenerative therapies because they have not been subjected to the cellular degradation that occurs with aging. Younger donor cells have higher levels of regenerative potential, including better proliferation rates, stronger signaling capacity, and greater ability to support tissue repair. In contrast, autologous cells, particularly in older individuals, may be less effective due to age-related decline in cell functionality (called senescence). As cells age, their regenerative capabilities decrease, making them less efficient at supporting healing and recovery. Using allogeneic cells provides a way to bypass these limitations and deliver more potent regenerative effects. Do the MSCs at LMI require matching like blood types? No, the mesenchymal stem cells (MSCs) used at LMI do not require matching. These cells are immunologically privileged, meaning they can be safely used in various patients without triggering an immune response. This unique property ensures our therapies are both safe and effective for everyone we treat. Why don’t the MSCs used at LMI need matching? The MSCs we use at LMI naturally avoid detection by the immune system because they lack the markers that typically cause immune rejection. This allows them to integrate seamlessly into treatments without requiring genetic compatibility, providing a simpler and more efficient regenerative solution. What makes the MSCs at LMI unique? The MSCs used in LMI therapies are carefully sourced from young, healthy donors to maximize their regenerative potential. We maintain rigorous standards in processing and quality control to ensure their immunologically privileged status, delivering the highest level of effectiveness for tissue repair, anti-inflammatory action, and rejuvenation. Are there risks to using unmatched MSCs in LMI treatments? No, the unmatched MSCs we use at LMI have a very low risk of immune rejection due to their immunologically privileged nature. This makes them a safe and reliable choice for our regenerative medicine therapies. How do MSCs at LMI improve access to regenerative treatments? Since our MSCs do not require genetic matching, patients can begin their treatments without delay. This eliminates the need to search for a matched donor, ensuring faster and more accessible regenerative therapies at LMI.

Why are MSCs a cornerstone of regenerative medicine at LMI? MSCs are integral to LMI’s regenerative medicine protocols due to their ability to promote healing, reduce inflammation, and repair damaged tissues. Their immunologically privileged status and robust regenerative capabilities enable us to deliver cutting-edge therapies that meet the unique needs of each patient. Do donor stem cells contain the donor’s DNA, and will that DNA be integrated into my body? Yes, donor stem cells naturally contain the donor's DNA, but this DNA will not integrate into your body or affect your genetic makeup. These cells function primarily through a process called paracrine signaling. They release beneficial growth factors and signals that encourage your own cells to heal and regenerate. The donor cells are temporary helpers

and do not permanently remain in your body or alter your DNA. Can donor stem cells change my DNA or affect my genetic traits?

No, donor stem cells cannot change your DNA or affect your genetic traits. They do not integrate into your genetic code. Their role is to stimulate your body's natural repair mechanisms by releasing signaling molecules that promote healing and tissue regeneration. This process is entirely supportive and does not involve altering your genetic information. How Does LMI Ensure the Quality and Safety of Stem Cells and Exosomes? Longevity Labs partners adhere to the highest standards, utilizing labs with international certifications, including ISO standards, GMP compliance, and AABB accreditation. Our state- of-the-art lab facilities ensure stem cells and exosomes maintain maximum viability and potency, providing top-tier treatment quality. Why is using fresh cells better than frozen cells for regenerative treatments? Fresh cells offer significant advantages over frozen cells because they are not subjected to the potential risks of freezing and thawing. Mesenchymal Stem Cells (MSCs) are highly sensitive, and the cryopreservation process can sometimes result in cellular damage, reduced viability, or diminished regenerative potential. At LMI, we prioritize using freshly cultured cells to ensure maximum viability and regenerative effectiveness. Fresh cells maintain their full functionality, with a viability rate of 98% or greater, and are free from the potential structural or functional alterations that can occur during freezing and thawing. By avoiding cryopreservation, we provide our patients

with the highest-quality cells for optimal therapeutic outcomes. What Conditions Can Be Treated with Stem Cell Therapy at LMI?

Stem cell clinical trials are rapidly growing, demonstrating their efficacy in treating conditions that develop chronic inflammation, such as like musculoskeletal diseases, neurological disorders. At LMI, our treatments are tailored to address a wide range of conditions, including:

Age-Related Conditions: Wrinkles/sagging skin, menopause, osteoporosis, osteoporosis- related fractures, cognitive decline, hearing loss, cataracts & age-related macular degeneration (AMD), hair loss, heart disease, balance disorders & fall prevention. Musculoskeletal Issues: Chronic pain, arthritis, tendon/ligament injuries, joint issues, spinal disc degeneration, sports injuries, tendon repair (Achilles, rotator cuff), osteoarthritis of the hip, osteogenesis imperfecta, fibromyalgia. Metabolic Disorders: Type II diabetes, obesity, type I diabetes, non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS). Reproductive & Sexual Wellness: Erectile dysfunction, libido decline, endometriosis, polycystic ovary syndrome (PCOS). Chronic Toxicities (Supported by Homotoxicology): Heavy metals, radiation, drug-related toxicities. Organ Conditions & Wounds: COPD, long-COVID, asthma, kidney disease, fatty liver, cirrhosis, diabetic foot, wound healing, chronic kidney disease (CKD), end-stage renal disease (ESRD), coronary artery disease, myocardial infarction (heart attack), acute respiratory distress syndrome (ARDS), peripheral artery disease (PAD), chronic sinusitis, cystic fibrosis, glaucoma, liver disease, burn injury recovery. Neurodegenerative Diseases: Alzheimer's, Parkinson's, multiple sclerosis, stroke recovery, ALS, spinal cord injuries, epilepsy, Guillain-Barre syndrome, hypoxic-ischemic encephalopathy (HIE), cerebral palsy. Autoimmune Diseases: Crohn's disease, ulcerative colitis, diverticulitis, hypothyroid, rheumatoid arthritis, lupus (SLE), psoriasis, systemic sclerosis (scleroderma), Sjögren's syndrome, psoriatic arthritis, ankylosing spondylitis, sarcoidosis, atopic dermatitis, eczema. Additional Conditions: Sleep disorders (insomnia, sleep apnea), autism, pancreatitis, Lyme disease, traumatic brain injury (TBI), chronic fatigue syndrome, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), post-traumatic stress disorder (PTSD), chronic venous insufficiency & varicose veins, HIV/AIDS-related immunodeficiency. What is the first-pass lung effect in stem cell IV treatments, and how does LMI address it? The first-pass effect occurs when a portion of stem cells, administered intravenously, becomes temporarily trapped in the lungs due to their size. While this may reduce the number of cells reaching other tissues initially, it’s not necessarily a bad thing. The lungs are one of the most critical organs for oxygenating your blood and supporting tissue health. The stem cells play a vital role in repairing and regenerating lung tissue, addressing any underlying issues or inflammation. At LMI, we recognize this as an added benefit, as healthier lung function directly enhances overall oxygen delivery and systemic recovery.

Additionally, LMI’s advanced protocols are designed to optimize stem cell distribution, ensuring therapeutic benefits to both the lungs and other target tissues, maximizing the regenerative potential. At LMI, we mitigate some of the first-pass effect using several proprietary strategies: • Oxygen supplementation during infusion improves oxygenation and reduces lung inflammation, helping the cells circulate more effectively. • Slower administration of stem cells minimize the risk of lung entrapment, allowing more cells to bypass the lungs and reach target areas. • Nutraceuticals as Natural Vasodilators: We also include natural neutraceutical vasodilators in our IV protocols, which help improve blood flow and reduce lung entrapment, further enhancing cell circulation. • Exosome therapy is also employed, as exosomes are smaller and bypass lung entrapment, providing a powerful addition to whole cells. These approaches significantly improve the efficacy and safety of our stem cell treatments. How does oxygen supplementation help during MSC administration? Oxygen supplementation improves the lung's microcirculation, reduces local hypoxia (low oxygen levels), and optimizes the pulmonary environment for MSC passage. This can:

• Decrease MSC trapping in the lungs.

• Enhance MSC viability and function by preventing hypoxia-induced stress.

• Support better distribution of MSCs to systemic target tissues. Are Stem Cell and Exosome Therapies Safe for Patients with Active Cancer? MSC and exosome therapies are not recommended for patients with active cancer due to the potential risk of stimulating tumor growth. These therapies are only considered safe after a patient has been in remission for at least five years and is under strict medical supervision. Why Does LMI Use AI MRI Screening Before Administering MSC and Exosome Therapies? At LMI, we prioritize safety by using AI-powered MRI screening to detect any undiagnosed cancer or any of over 500 conditions before treatment. This high-precision screening ensures that MSC and exosome therapies are appropriate for each patient. What if I Tried Stem Cell Treatments in the Past and Did Not Notice Any Benefits? While stem cell therapies have reported an average of 80% success rate (defined as an improvement in the condition), individual results depend on several factors, including the specific condition being treated and the quality and type of the stem cells used. At LMI, we ensure that you receive the right type of stem cell for your needs, and we follow stringent protocols for for harvesting, culturing, and processing to maintain at least 98% cell viability

(live cells). This ensures the highest possible effectiveness, giving you a better chance of seeing significant results. Is the Stem Cell Treatment Procedure Painful? Stem cell IV infusions at LMI are generally painless and similar to a standard IV. A topical anesthetic is sometimes applied to ensure patient comfort throughout the process. How long does a stem cell treatment session take? The length of a stem cell treatment session can vary depending on the quantity of stem cells being administered. Typically, it takes about 30-60 minutes for the IV infusion. Before or after the stem cells are infused, a nutraceutical IV is administered to nourish your cells. Our team will closely monitor you throughout the entire procedure to ensure your comfort and safety. What Can I Expect to Feel After a Stem Cell IV Infusion? Post-treatment experiences can vary. Some patients may feel mild euphoria or increased energy, while others may feel fatigued as their body starts the healing process. Side effects like light headaches or dizziness happen occasionaly and will generally resolve quickly. How Does Oxygen Supplementation Enhance MSC and Exosome Therapy? Oxygen supplementation enhances MSC and exosome therapies by improving tissue oxygenation, supporting angiogenesis, and boosting the cells' regenerative capacity. This helps maximize the treatment's effectiveness. How Long Does It Take to See Results from Stem Cell Treatment? Results from stem cell therapy may start to appear within a day or weeks for some patients, while others may take several months to notice significant improvements. Full effects are often seen six months after treatment. What are the Potential Adverse Reactions During Stem Cell IV Treatments, and How Common Are They? While stem cell IV treatments are generally safe, some patients may experience mild to moderate reactions. Common side effects include fever, chills, headaches, and fatigue, which occur in less 5% of patients. These symptoms are usually mild and resolve within a few hours. Severe allergic reactions are extremely rare, and are managed with appropriate interventions by our doctors. Our doctors will evaluate your medical history and overall health condition to assess the likelihood of an adverse reaction and determine the most suitable preventive measures for your treatment.

What Does LMI do to Mitigate Adverse Reactions During Stem Cell IV Treatments? The doctors at LMI may decide, based on your condition, to use a low-dose antihistamine to prevent allergic and inflammatory responses, ensuring a safer and more effective treatment without compromising cell efficacy. Unlike corticosteroids, which are used by many other clinics and interfere with the stem cells' ability to do their job, as well as cause undesirable side effects like insomnia, edema, weight gain, and elevated blood pressure, antihistamines control histamine release without affecting the regenerative potential of the cells. By avoiding corticosteroids, we preserve the full therapeutic potential of your treatment. Our doctors thoroughly review your medical history and current condition to tailor a premedication protocol that is specific to your needs, providing both safety and optimal efficacy for your treatment. Is Stem Cell Therapy at LMI Covered by Health Insurance? No, all treatments at LMI are paid on a cash basis. Payments can be made via wire transfer or credit card, and an advance deposit may be required for your first appointment. What Are the Average Costs for Stem Cell and Exosome Treatments at LMI? Regenerative medicine treatments start at $3,750 per office visit. For those opting for a one- week or two-week medical vacation, treatment packages average around $15,000 to $25,000, respectively, depending on the specific therapies included. If patients opt to stay in the LMI condos, that would be an additional cost. The exact price will vary based on your unique medical needs and the personalized treatment plan designed by our expert team, and your choices on the VIP packages. A detailed cost estimate will be provided after an in- depth consultation to ensure you receive the best possible care for your needs. What Are the Advantages of Stem Cell Therapy Compared to Surgery? Stem cell therapy offers several advantages over surgery, including shorter recovery times, fewer risks, no general anesthesia, and no scarring since it's an injection-based procedure. What are Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs) and how are they sourced? Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs) are "multipotent" cells derived from the umbilical cord of newborns. These cells are ethically sourced from tissue that is typically discarded after birth, providing an abundant and responsible source of stem cells. What are the benefits of WJ-MSCs? WJ-MSCs are known for their exceptional regenerative and anti-inflammatory properties. They are particularly effective for treating age-related conditions, reducing inflammation, modulating the immune system, and supporting tissue repair.

What conditions can WJ-MSCs help treat? WJ-MSCs are especially useful in addressing musculoskeletal issues, enhancing sexual wellness, managing autoimmune disorders, and improving cardiovascular health. What are Placental Mesenchymal Stem Cells (P-MSCs) and how are they sourced? Placental Mesenchymal Stem Cells (P-MSCs) are "multipotent" stem cells sourced ethically from the placenta, which is typically discarded after birth. This provides a rich and abundant source of stem cells without the need for invasive harvesting. What are the benefits of P-MSCs? A: P-MSCs deliver cutting-edge regenerative therapies that promote healing, reduce inflammation, enhance immune modulation, and restore tissue function. What conditions can P-MSCs help treat? P-MSCs (Placental Mesenchymal Stem Cells) are particularly effective in reducing inflammation, treating sports injuries, and promoting muscle regeneration. Their strong potential for muscle differentiation and repair makes them an ideal option for conditions involving tissue damage and inflammation. What are Adipose-Derived Mesenchymal Stem Cells (ad-MSCs) and how are they sourced? Adipose-Derived Mesenchymal Stem Cells (ad-MSCs) are powerful, multipotent stem cells sourced from the fat of young, healthy donors. Known for their ability to promote tissue repair and regeneration, ad-MSCs are particularly valuable in cosmetic applications, such as improving skin elasticity, reducing the appearance of fine lines and wrinkles, and supporting overall skin rejuvenation. Their regenerative properties make them a popular choice for enhancing the body's natural ability to restore a youthful appearance. What are Endometrial Mesenchymal Stem Cells (eMSCs) and how are they sourced? Endometrial Mesenchymal Stem Cells (eMSCs) are "multipotent" stem cells ethically sourced from healthy menstruating females in their mid-twenties. These cells are highly regenerative and possess potent immunomodulatory properties. What are the benefits of eMSCs? eMSCs are particularly beneficial for treating a range of gynecological conditions, including endometriosis, uterine fibroids, polycystic ovary syndrome, and menopausal or reproductive health issues. They also promote vascular regeneration and tissue repair, making them promising for enhancing fertility and improving overall uterine health. What are Human Pluripotent Stem Cells (hPSCs), and why are they not used at LMI? Human Pluripotent Stem Cells (hPSCs) are derived from sources such as embryos or induced cells from umbilical cord blood or skin. These cells have the unique ability to differentiate into over 220 cell types, making them highly versatile. However, this pluripotent

nature also comes with significant risks, including the potential to form tumors or cancerous growths. To prioritize patient safety, LMI exclusively uses multipotent stem cells, which are more specialized and have a much lower risk of tumorigenicity, providing a safer approach to regenerative medicine. Why does LMI prioritize multipotent stem cells over pluripotent stem cells? While pluripotent stem cells (hPSCs) derived from embryos, skin, or induced umbilical cord blood have the ability to transform into almost any cell type, this versatility increases the risk of forming tumors or cancerous growths. Multipotent stem cells, which LMI exclusively uses, are safer because they are naturally limited to specific types of tissue differentiation. Our cells deliver powerful regenerative benefits without the elevated risks associated with pluripotent cells, making them a more secure and effective choice for patient treatments. Why is it unlikely that stem cell therapy will become a standard treatment in the U.S.? A recent court ruling by the Ninth Circuit Court of Appeals classified therapies involving stromal vascular fraction (SVF) - a stem cell product derived from processed fat tissue—as a "drug" under the Federal Food, Drug, and Cosmetic Act (FDCA). This decision requires such treatments to undergo FDA regulation, including approval through Investigational New Drug (IND) applications and clinical trials. Similarly, stem cell products derived from Wharton’s Jelly (WJ) are subject to the same regulations if they undergo significant manipulation or are used for non-homologous purposes. These strict requirements make it difficult for many stem cell therapies to be widely adopted as standard treatments in the U.S. What is the FDA “minimally manipulated” standard, and how does it affect stem cell therapies? The FDA requires that stem cell products be "minimally manipulated" to avoid classification as drugs. This means that the cells must not undergo significant processing or alteration beyond what is necessary to prepare them for their intended purpose. Many therapeutic applications, including those that involve isolating or expanding cells, fall outside this definition, subjecting them to FDA regulation. As a result, treatments often contain low cell counts and are less likely to provide meaningful therapeutic benefits under this standard. Can clinics in the U.S. still offer stem cell therapies? Yes, but only under strict FDA regulations. Clinics offering therapies involving significantly processed stem cells, such as adipose-derived SVF or WJ-derived stem cells, must comply with FDA guidelines. This includes conducting clinical trials, proving safety and efficacy, and adhering to Good Manufacturing Practices (GMP). Non-compliant clinics risk legal action, fines, or injunctions. For many clinics, meeting these regulatory demands is financially and logistically challenging, limiting the availability of advanced stem cell therapies in the U.S. What does this mean for patients seeking advanced stem cell therapies? Patients in the U.S. may face limited access to advanced stem cell therapies due to regulatory restrictions. Treatments involving expanded or processed stem cells, such as those offered at LMI, are not available outside of clinical trials in the U.S. This ruling emphasizes the importance of seeking treatment from reputable clinics that comply with

international standards and ensure patient safety, such as LMI, which offers cutting-edge therapies that go beyond what is currently allowed in the U.S. Exosomes FAQ's What Are Exosomes and How Do They Work in Regenerative Medicine? Exosomes are small particles released by cells that carry proteins, lipids, and genetic material to other cells, acting as messengers. They promote healing by reducing inflammation, stimulating cell repair, and supporting regeneration. Exosomes are an important part of regenerative medicine as they enhance the body's natural healing processes. How Are Exosomes Different from Stem Cells? While stem cells can develop into different cell types, exosomes do not become new cells themselves. Instead, they communicate with other cells, delivering signals that trigger repair, growth, and healing. Exosomes complement stem cell therapies by amplifying the healing and regenerative effects. What Conditions Can Exosome Therapy Help Treat? Exosome therapy has shown promise in treating a wide range of conditions, including joint pain, soft tissue injuries, chronic inflammation, neurodegenerative diseases, and skin rejuvenation. They are often combined with stem cell therapies to maximize the healing process. Is Exosome Therapy Safe? Yes, exosome therapy is considered safe when administered by trained professionals. Since exosomes are naturally produced by the body and do not involve live cells, the risk of rejection or complications is minimal. At LMI, we use rigorously tested exosomes to ensure the highest safety standards. How Are Exosomes Used Alongside Stem Cell Therapy to Maximize Regenerative Effects? At LMI, Exosomes are often combined with stem cell therapy to enhance overall regenerative outcomes. While stem cells repair or replace damaged tissue, exosomes amplify the healing process by sending signals that stimulate further tissue repair, reduce inflammation, and accelerate recovery. Together, they create a more powerful and

comprehensive approach to healing. Natural Killer (NK) Cells FAQs

What are Natural Killer (NK) Cells and how do they work? Natural Killer (NK) Cells are a type of immune cell that plays a key role in the body's defense system by identifying and destroying abnormal cells, such as virus-infected or cancerous

cells. They are part of the body's natural immune response and help maintain overall health by detecting and eliminating threats before they can cause harm. How are NK Cells used in regenerative medicine at LMI? At LMI, NK Cells are used to enhance the body's immune response, particularly for patients with compromised immune systems or those recovering from illnesses. NK Cell therapy is designed to boost the body's ability to fight infections, target abnormal cells, and support overall wellness, making it a powerful complement to regenerative treatments. Why are Natural Killer (NK) cells sourced from cord blood? Cord blood is a highly valuable source for Natural Killer (NK) cells because it contains young, potent immune cells with robust cytotoxic activity. NK cells derived from cord blood are more effective due to their immaturity and greater capacity for expansion and activation. These cells are less likely to trigger adverse immune reactions, making them ideal for therapeutic applications. Are cord blood-derived NK cells safe and effective? Yes, NK cells sourced from cord blood are considered safe and effective. Their natural immunomodulatory and cytotoxic properties allow them to target infected or abnormal cells, such as cancerous cells, while leaving healthy tissues unaffected. The process of sourcing and preparing these cells is tightly controlled to ensure their safety, purity, and potency for therapeutic use. Why does LMI use cord blood-derived NK cells? At LMI, we prioritize cord blood-derived NK cells for their superior therapeutic benefits, including enhanced targeting of abnormal cells, higher activation potential, and a lower risk of adverse immune reactions. This ensures the most effective and safest treatment options for our patients, leveraging cutting-edge regenerative and immunotherapy techniques that go beyond what is typically available in traditional clinics. What conditions can NK Cell therapy help treat? NK Cell therapy has shown promise in treating various conditions, including cancer (especially in patients in remission), autoimmune disorders, chronic viral infections, and general immune system dysfunction. It is also used to support overall immune health, particularly in individuals recovering from illness or undergoing other therapies. Is NK Cell therapy safe? Yes, NK Cell therapy is considered safe when administered under medical supervision. Since NK Cells are naturally part of the body's immune system, the risk of adverse reactions is low. At LMI, we use rigorously tested protocols to ensure that NK Cell therapy is both safe and effective for our patients.

Can NK Cell therapy be combined with other treatments? Absolutely. NK Cell therapy is often combined with other regenerative therapies, such as stem cell or exosome treatments, to enhance the overall healing process. By boosting the immune system's ability to target abnormal cells, NK Cell therapy helps maximize the effectiveness of other treatments and supports long-term health. How Can I Schedule a Consultation at LMI? You can schedule a consultation by contacting us through our website or calling our office. Our team will guide you through the process and answer any questions you may have. Hyperbaric Oxygen Therapy (HBOT) FAQs What is Hyperbaric Oxygen Therapy (HBOT)? HBOT is a non-invasive treatment where patients breathe 96%+ pure oxygen in a pressurized chamber. This therapy increases oxygen levels in the bloodstream and tissues, enhancing healing, reducing inflammation, and supporting the body’s natural regenerative processes. What makes LMI’s HBOT chambers unique? At LMI, our HBOT chambers are designed with patient comfort and accessibility in mind. Unlike traditional lay-down chambers, our chambers allow patients to be seated comfortably. This design makes it easier to get in and out of the chamber, making the treatment accessible for individuals with mobility challenges or those who prefer a more upright position. Additionally, the spacious seating arrangement helps reduce feelings of claustrophobia, which are common in enclosed, lay-down chambers. What pressure levels are used in HBOT at LMI? We offer three advanced HBOT systems with adjustable pressures up to 2.0 ATA (atmospheres absolute). Pressure levels are tailored to suit individual needs and medical conditions, ensuring safe and effective treatment for every patient. How is the pressure customized for different conditions? The pressure used during HBOT is adjusted based on the patient’s condition and therapeutic goals. For example, lower pressures may be used for neurological conditions to minimize risks, while higher pressures are applied for musculoskeletal injuries or advanced wound healing to enhance oxygen delivery and efficacy. Is HBOT safe, and what are the potential side effects? HBOT is a safe, FDA-approved therapy when administered by trained professionals. At LMI, we follow strict safety protocols and provide continuous patient monitoring. Potential side effects, such as mild ear discomfort, sinus pressure, or temporary fatigue, are rare and typically resolve quickly. Gradual pressurization and depressurization are used to ensure patient comfort and safety.

Why does LMI use 96%+ pure oxygen? Using 96%+ pure oxygen ensures the maximum therapeutic benefit by significantly increasing the oxygen saturation in the bloodstream and delivering it to tissues. This enhanced oxygenation promotes faster healing, tissue regeneration, and reduced inflammation. How many HBOT sessions are typically required? The number of sessions depends on the individual’s condition and therapeutic goals. Acute conditions may require fewer sessions, while chronic conditions or anti-aging treatments may involve a more extended treatment plan for optimal results. Can HBOT slow the aging process? Yes, HBOT can slow the aging process by improving skin health, boosting collagen production, reducing oxidative stress, and enhancing cellular repair. At LMI, HBOT is a key component of our personalized anti-aging programs to promote overall vitality and longevity. Plasma Exchange Therapy (Plasmapheresis) FAQs What Is Plasma Exchange Therapy (Plasmapheresis) and How Does It Work? Plasma Exchange Therapy, or Plasmapheresis, is a procedure that removes harmful substances, such as antibodies and inflammatory proteins, from the blood. This process supports the immune system and improves overall health by reducing the burden of these harmful components in the body. Who Can Benefit from Plasmapheresis? Plasmapheresis is particularly beneficial for patients with autoimmune diseases like multiple sclerosis and lupus, chronic conditions such as long COVID, and certain neurological or hematological disorders. It can also be used preventively to reduce the risk of disease exacerbation. What Conditions Can Be Treated with Plasmapheresis? Plasmapheresis is effective in treating: • Autoimmune Diseases: Multiple sclerosis, lupus, myasthenia gravis, and more. • Neurological Disorders: Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP), etc. • Long COVID: Helps reduce persistent symptoms by removing inflammatory proteins and antibodies linked to the condition. • Blood Disorders: Such as thrombotic thrombocytopenic purpura (TTP). Is Plasmapheresis Safe? Yes, Plasmapheresis is a safe procedure when performed by experienced medical professionals. While there are minimal risks, such as potential allergic reactions or temporary changes in blood pressure, the procedure is closely monitored to ensure patient safety.

What Can I Expect During a Plasmapheresis Session? During a session, you will be seated or lying down comfortably. Blood is drawn from one arm, processed through the Plasmapheresis machine, and returned to your body through the other arm. The procedure typically takes 1-3 hours, and most patients can resume

normal activities shortly afterward. Ozone (O3) Therapy FAQs

What is ozone therapy, and how does it work? Ozone therapy is a treatment that uses medical-grade ozone, a highly reactive form of oxygen, to promote healing and wellness. When administered, it increases oxygen levels in the body, stimulates the immune system, and enhances cellular energy production, leading to improved overall health. What are the detoxifying benefits of ozone therapy? Ozone therapy helps eliminate harmful toxins from the body by supporting liver function, improving circulation, and boosting the body’s natural detoxification processes. It can neutralize free radicals, enhance antioxidant defenses, and improve cellular waste removal, promoting a cleaner and more balanced internal environment. How does ozone therapy support overall health? By increasing oxygenation at the cellular level, ozone therapy reduces inflammation, supports tissue repair, and strengthens the immune system. Its ability to combat oxidative stress also makes it a valuable therapy for managing chronic conditions and enhancing vitality. Why is ozone therapy considered beneficial for detoxification? Patients often value ozone therapy for its powerful detoxifying properties, as it assists the body in removing heavy metals, environmental pollutants, and other toxins. This cleansing effect not only improves physical health but also supports mental clarity and overall well- being. What conditions can Ozone Therapy treat? Ozone Therapy has been shown to be effective for a variety of conditions, including:

Chronic joint pain and arthritis

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Soft tissue injuries Chronic inflammation Autoimmune disorders

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Accelerated healing after surgeries

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• At LMI, ozone is also used as part of our regenerative and anti-aging treatment protocols to enhance overall vitality.

Is Ozone Therapy safe? Yes, Ozone Therapy is considered safe when administered by trained professionals in controlled settings, like at Longevity Medical Institute. We use medical-grade ozone, and the therapy is carefully tailored to your health condition. While ozone is powerful, treatments are designed to be non-invasive and to promote healing without side effects. Anti-Aging Treatments FAQs How does aging impact the skin, muscles, and deeper tissues of the body? Aging leads to visible and functional changes in the skin, muscles, and deeper tissues, resulting in wrinkles, fine lines, sagging skin, and decreased elasticity. These changes can affect confidence, health, and quality of life. What is the goal of anti-aging therapies at LMI? At LMI, our anti-aging therapies aim to rejuvenate, restore, and enhance your natural beauty and vitality using cutting-edge treatments that address both visible signs of aging and overall tissue health. What types of anti-aging treatments does LMI offer? LMI provides a wide range of anti-aging treatments, including:

• Injectables to reduce wrinkles, restore volume, and hydrate the skin.

• Advanced laser systems to improve skin texture, tone, and address pigmentation issues, vascular concerns, and scarring. • Diagnostic technologies for personalized treatment plans tailored to individual needs. What specific benefits do LMI's anti-aging therapies provide? LMI’s therapies are designed to:

• Reduce visible signs of aging, such as wrinkles and fine lines.

• Restore volume and elasticity by stimulating natural collagen and hydrating the skin.

• Improve skin texture and tone, addressing pigmentation issues, vascular concerns, and scarring. • Enhance overall well-being with non-invasive or minimally invasive solutions tailored to individual needs. What advanced diagnostic tools are used at LMI for personalized treatment plans? • VISIA Imaging : A cutting-edge skin analysis system providing a comprehensive assessment of your skin's health, enabling highly personalized care.

What laser systems are available at LMI, and how do they benefit patients?

• Cutera Xeo Navigator : A multi-application aesthetic technology addressing skin revitalization, pigmented lesions, and vascular concerns. • Lumenis AcuPulse with FemTouch : The AcuPulse treats wrinkles, scars, and skin laxity, while the FemTouch attachment improves vaginal health by addressing atrophy, dryness, and laxity. How does LMI ensure a personalized anti-aging experience? LMI uses diagnostic imaging and tailored treatment plans to address the unique concerns of each patient. This ensures that all therapies are specifically designed to meet individual needs and goals. What Should I Avoid After Anti-Aging Treatments? After treatments like injectables, laser therapy, or PRP, it’s important to follow post-treatment care to maximize results and minimize side effects: • Avoid excessive sun exposure: Protect treated areas with sunscreen and avoid direct sunlight to prevent hyperpigmentation or irritation. • Refrain from strenuous exercise: For at least 24-48 hours, avoid activities that increase blood flow to the face, such as heavy workouts, to reduce the risk of swelling or bruising. • Avoid alcohol and blood-thinning medications: These can increase the likelihood of bruising after injectables or PRP treatments. • Do not touch or massage treated areas: This is particularly important for fillers and Dysport to ensure the product settles correctly. • Skip skincare with active ingredients: For a few days, avoid products with retinoids, glycolic acid, or harsh exfoliants that can irritate the skin after lasers or PRP therapy. Your provider will give you tailored aftercare instructions based on your specific treatment. How Does Stem Cell Therapy Support Anti-Aging? Stem cell therapy revitalizes tissues from the inside out, improving skin elasticity, reducing wrinkles, and enhancing overall vitality. Beyond cosmetic benefits, it promotes organ and tissue function, supporting a youthful appearance and overall health. What Is the Difference Between Cutera Xeo and Lumenis AcuPulse Treatments? • Cutera Xeo: A versatile laser system offering skin rejuvenation, vascular lesion treatment, and pigment correction for a smoother, clearer complexion. • Lumenis AcuPulse: A CO2 laser designed for deeper skin resurfacing to treat wrinkles, scars, and uneven texture, promoting collagen production and long-term skin renewal.

Are LMI’s Anti-Aging Treatments Safe? Yes, all treatments at LMI are performed by experienced medical professionals using FDA- approved products and technologies. Patient safety and satisfaction are our top priorities,

and treatments are tailored to individual needs and goals. What Can I Expect from Anti-Aging Treatments at LMI?

Most treatments involve minimal downtime. Botox and Dysport require no recovery, while fillers, lasers, exosome therapy, and PRP treatments may cause mild redness or swelling that subsides within a few days. Your provider will give detailed post-treatment care instructions to maximize results. How Do I Choose the Right Anti-Aging Treatment for Me? During your consultation, our specialists will use tools like Visia Skin Analysis to assess your skin’s condition and discuss your health history, lifestyle, and goals. Based on this, they will recommend a customized treatment plan tailored to your needs. What Are the Benefits of the Vampire Facelift? The Vampire Facelift combines Platelet-Rich Plasma (PRP) with dermal fillers to stimulate collagen production, improve skin texture, and restore facial volume. This non-surgical treatment offers a natural and rejuvenated appearance with long-lasting effects. How Does Stem Cell Hair Restoration Contribute to Anti-Aging? Stem Cell Hair Restoration combines stem cells and PRP to stimulate hair follicles, improving hair density and promoting natural regrowth. This non-surgical procedure addresses hair thinning and loss, helping patients maintain a youthful, vibrant appearance. IV Vitamin, Peptide Therapy, and Homotoxicology FAQs What is Boost IV Therapy, and How Does It Improve Vitality? Boost IV Therapy is formulated with high doses of Vitamin C, B-complex vitamins, Magnesium, and Zinc to enhance energy, support immune function, and improve overall wellness. It is ideal for patients experiencing fatigue, low energy, or as a preparatory step before regenerative treatments like stem cell therapy. How Does Detox IV Therapy Support the Body’s Natural Detoxification? Detox IV Therapy combines antioxidants like Glutathione, Alpha-lipoic acid, and Selenium to assist the body in eliminating toxins and reducing oxidative stress. This therapy prepares the body for regenerative treatments and aids recovery from environmental toxin exposure, supporting optimal cellular health. What Are the Benefits of Recovery IV Therapy? Recovery IV Therapy includes amino acids such as Glutamine and Arginine, along with anti- inflammatory agents and antioxidants. It accelerates the healing process after surgeries or injuries and helps reduce inflammation, making it ideal for patients recovering from intensive physical or medical interventions.

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