Papilocare® rst treatment with clinical superiority vs. spontaneous clearance in HPV+ patients over 40 with cervical lesions ◊2, 3 AGE IS AN INDEPENDENT FACTOR THAT INFLUENCES LESION PROGRESSION
Normalisation of lesions in women HPV+ and over 40 years old 2
CLINICAL TRIAL
*
*
100%
p=0.007
p=0.003
NCT 04002154
90%
80%
92% (n=24/26)
90% (n=19/21)
70%
Subanalysis over 40
60%
50%
50%
40%
(n=6/12)
30%
33%
20%
(n=3/9)
10%
Control group
Papilocare® group
0
Total population
High-risk HPV subpopulation
n=38
n=30
HPV+ clearance
Regression of cervical lesions ◊ in HPV+ patients
OBSERVATIONAL STUDY
80
NCT 04002154
60
73
72
HPV+ patients over 40 years old 3
40
28
20
19
0
VISIT 1 (Baseline)
VISIT 2 6 MONTHS
VISIT 1 (Baseline)
VISIT 2 6 MONTHS
1. Bekos C, Schwameis R, Heinze G, Gärner M, Grimm C, Joura E, Horvat R, Polterauer S, Polterauer M. Inuence of age on histologic outcome of cervical intraepithelial neoplasia during observational management: results from large cohort, systematic review, meta-analysis. Sci Rep. 2018 Apr 23;8(1):6383. doi: 10.1038/s41598-018-24882-2. PMID: 29686397; PMCID: PMC5913272. 2.Gil-Antuñano, S.P.; Serrano Cogollor, L.; López Díaz, A.C.; González Rodríguez, S.P.; Dexeus Carter, D.; Centeno Mediavilla, C.; Coronado Martín, P.; de la Fuente Valero, J.; López Fernández, J.A.; Vanrell Barbat, C.; et al. Ecacy of a Coriolus versicolor-Based Vaginal Gel in Human(Papillomavirus-Positive Women Older Than 40 Years: A Sub-Analysis of PALOMAStudy. J. Pers. Med. 2022, 12, 1559. 3. Cortés Bordoy, Javier et al. “E"ect of a Multi-Ingredient Coriolus-versicolor-Based Vaginal Gel in Women with HPV-Dependent Cervical Lesions: The Papilobs Real-Life Prospective Study.” Cancers vol. 15,15 3863. 29 Jul. 2023, doi:10.3390/cancers15153863. ◊ Low grade cervical lesions ASCUS/LSIL
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