Maltese et al. 2015
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Maltese G, Karalliedde J, Rapley H, Amor T, Lakhani A, Gnudi L. A pilot study to evaluate the efficacy of class IV lasers on nonhealing neuroischemic diabetic foot ulcers in patients with type 2 diabetes. Diabetes Care. 2015 Oct;38(10):e152-3.
Design: Pilot Study Subjects: 11 patients with type 2 diabetes who were nonresponsive to conventional treatment for at least 12 weeks Methods: Participants were allocated to two groups: • Laser treatment was delivered once a week prior to standard care and dressing (laser) (n=5), • Standard treatment group (control) (n=6). Standard care for DFUs included antibiotic treatment, dressing, and off- loading, was similar in both groups. Outcomes included: Complete healing of Ulcer. Results: • Both groups had similar ulcer size and duration, renal function and age. • Within the 12-week follow-up, four of five laser-treated patients (80%) had a complete ulcer resolution (most ulcers healed after 4.6 weeks). • In the control group, no ulcer healing occurred by week 12 (zero out of six patients). • Levels of renal function and peripheral arterial disease were maintained in the laser group.
Key message: High power laser therapy along with standard care resulted in complete ulcer healing of neuroischemic DFUs in 80% of participants.
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