SUNDAY, OCTOBER 2, 2022
WORKSHOP PROGRAM Large-scale genotype/phenotype collections: community opportunities & data-sharing Over the last decade, opportunities to expand genetic knowledge about health and normal variation in companion animals have been facilitated by availability of genotype-phenotype databases, analogous to large-scale efforts for humans such as dbGAP or the UK Biobank. Several such collections exist for companion animals carried out by direct-to-consumer genetic testing endeavors and non-profit efforts, but the approaches and opportunities to make use of these collections are a work-in-progress. This workshop will feature brief presentations by leaders of major efforts followed by a facilitated discussion on future plans, opportunities for data-sharing, standardization, and academic collaborations. Elinor Karlsson, PhD, UMass Chan Medical School, USA Reference genomes, assemblies, and annotations: applications and approaches Assemblies and their annotation are essential tools of biological research. The assembly — the DNA content of a single genome — is typically represented in haploid or diploid forms. With the evolution of 3rd generation sequencing and scaffolding techniques, production of accurate and contiguous assemblies is becoming increasingly routine. Annotation provides context to the DNA that is represented within the assembly. Transcript isoform models, DNA conservation, ChIP-, CAGE-, and ATAC-seq data are but a few examples of annotation data that enrich assemblies. In this workshop, we will discuss where the dog and cat community has come and where it must go to advance our research interests community-wide. Jeff Schoenebeck, PhD, University of Edinburg, UK, Hannes Lohi, PhD, University of Helsinki, FI, Christophe Hitte, PhD, University of Rennes, FR 99 Lives Project The current progress for the 99 Lives dataset and implementation of the new cat reference genome Fca126 will be discussed. Sub-committees will be developed for disease / trait related community projects. Needed genomic resources will be reviewed and discussed to support the cat research community. Leslie Lyons, PhD, University of Missouri, USA Dog 10K Project The Dog 10K Consortium is an international collaboration of researchers from across the globe, launched in 2019, led by Dr. Ostrander at the National Institutes for Health. The aim of the Dog 10K is to coordinate the global effort on genome sequencing in dogs and build a comprehensive resource for the canine community to increase the understanding of the evolutionary history of dogs, genetic changes associated with domestication, and relationships of genetic changes to phenotype. Elaine Ostrander, PhD, National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH), USA
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