Conclusions
PDAC
8 m/min
16 m/min
Growth and invasion
No change —
No change —
Desmoplasia
No change —
No change —
CAF abundance
Reduces
Reduces
myCAF/iCAF ratio
Increases
Increases
CAF-related cytokine expression
Reduces
Reduces
• Exercise decreases the total amount of CAFs and alters the CAF composition by increasing myCAF and reducing iCAF.
• Due to the relevance of the CAF heterogeneity in PDAC chemoresistance and immunosuppression, further studies are needed to test the synergistic effect of exercise with chemotherapy or ICB on tumor growth.
Thanks for your attention
Keri Schadler Lab
Riccardo Ballarò rballaro@mdanderson.org @BallaroRiccardo
Jonghae Lee, PhD Sumedha Pareek Hetal Patel
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