Temperature Control, Engineered.
American-Made Infrastructure Inside the Cold Chain
When a bridge collapses, everyone notices. When a power grid fails, it dominates headlines.
The shift introduced new vulnerabilities: uncontrolled transit routes, regional temperature extremes, and dwell time on front porches in peak summer heat. “Cold” is no longer sufficient. “We designed and engineered products specifically for use cases,” Griffin explains. “Our food products and how we pack them out are different than our pharmaceuticals.” That difference — between chilling a product and maintaining a validated thermal environment — is what moved Coldkeepers beyond packaging supply into engineered systems. Domestic Manufacturing as Risk Mitigation In a sector heavily influenced by imports and extended production cycles, Coldkeepers built its model around domestic control. “Virtually everything that we manufacture and do is U.S.-based — materials, all of our manufacturing,” Griffin says. “There are a few minor products that we offer that are imported, but 90% to 99% of everything we sell is U.S.-made.” Manufacturing operations in Thomasville, Georgia, position the company near major interstate corridors and within rapid reach of Gulf Coast disaster zones.
But when a biologic arrives at 11°C instead of 8°C, nothing looks broken.
The box appears intact. The label reads correctly. The contents feel cool to the touch. And yet the product inside may already be compromised. That narrow margin — only a few degrees — is where Coldkeepers has operated since 1998. Not in visible infrastructure, but in the space where temperature determines whether something is safe, effective, or unusable. Founded as one of the early pioneers in modern cold chain packaging, Coldkeepers began with insulated solutions for last-mile delivery. Today, temperature-sensitive goods move routinely through e-commerce networks, direct-to-patient pharmaceutical programs, and specialty food distribution. “Shipping to people’s homes, and especially after COVID, has taken off immensely,” says Jeffrey Griffin, Director of Business Development and Sales. “People used to go to drugstores or grocery stores and never think about those things being delivered to their home. Today, it’s become a common practice. Every day.”
Corrugated Cardboard Box • A one-stop shop/single-source supplier opportunity • High-quality and available in 8, 10, 12 and 14 cube • Coldkeepers branded and keeps continuity with our liners
For and emergency response agencies, that speed matters. Domestic healthcare systems production shortens lead times, reduces freight volatility, and supports surge deployment when hurricanes, wildfires, or grid failures disrupt regional supply chains. n disaster conditions, temperature- controlled packaging becomes part of public health protection. “In a disaster, it’s twofold,” Griffin explains. “One, to maintain food safety and medication safety. And then the second part is getting much-needed food, much-needed medication to the site safely.” JEFFREY GRIFFIN DIRECTOR OF BUSINESS DEVELOPMENT & SALES
“We have a global patent on one- piece construction. All six sides of a box are completely sealed. There’s no thermal gaps.”
Medication degradation is not visible.
Eliminating the Thermal Gap
“Most pharmaceuticals have to stay between 2°C and 8°C,” Griffin says. “Reaching 0°C causes flash freezing. which changes the compound and inhibits the medication, destroying biologics. And the destroying biologics. And the same thing to go above 8°C. It can end up being toxic.” When refrigeration access is compromised and ambient heat intensifies, those parameters become harder to maintain — and far more consequential. Coldkeepers designs around that reality without relying on powered refrigeration systems that add cost and complexity.
A defining differentiator for Coldkeepers is its globally patented one-piece construction.
Traditional EPS coolers rely on separate lids and multi-piece assemblies. Seams shift. Small inconsistencies accumulate. “We have a global patent on one-piece construction,” Griffin says. “All six sides of a box are completely sealed. There’s no thermal gaps.” By eliminating seam variability, the system stabilizes internal conditions across long-haul routes and changing climates.
Performance is validated both in environmental chambers and in field testing.
Extreme Insulated Mailers • Thick padded mailers cushion and insulate up to 36 hours* • Metallic thick foam with metallized PET exterior • Multiple closures available: tape, zipper and slider • Film FDA Compliant for incidental food contact • Custom sizes available upon request
One-Piece Extreme Liners • Cold chain protection for medical supplies • FDA compliant/suitable for 24-48-hour shipments • Use with gel packs or dry ice for extended transit times • Patented one piece design, stores, and ships flat • Premium insulation allows for more payload space by reducing wall thickness
Penguin Expanding Insulated Mailers
“There is no true test other than real- world,” Griffin explains. “If they’re shipping from Phoenix to Washington, D.C., we test it. It’s 110 degrees in Phoenix and 45 degrees in D.C. How does that change the packaging? What do we need to do differently?” “Virtually everything that we manufacture and do is U.S.-based — materials, 90% to 99% of everything we sell is U.S.-made.”
The emphasis is not volume — it is control.
“It’s not really about the products,” Griffin says. “It’s about the solution.” Cold Chain Is an Exact Science Oversimplification remains one of the industry’s biggest risks. “People think, ‘Oh, I’ve got to keep this cold.’ There’s a lot more to it,” Griffin says. “They think I’ll throw a gel pack in something and it’ll be fine. It doesn’t work that way.” Pack-out configuration requires calculated refrigerant placement, insulation layering, and buffering to prevent flash freezing while
Curbside Recyclable One- Piece Insulated Liners
Cold chain packaging has historically relied on EPS and molded coolers that persist in landfills for centuries. “EPS stays in the landfill for over 500 years,” Griffin says. Coldkeepers developed a curbside recyclable product line built primarily from paper-based insulation with a thin internal moisture barrier. “It is certified by Western Michigan University to be curbside recyclable,” Griffin explains. “It’ll fit in your municipal recycle bin. And it actually outperforms styrofoam.” Sustainability Without Compromise
Performance was not sacrificed.
“An inch of our paper insulation will outperform an inch and three quarters of EPS,” he says. “They cost the same, they perform the same. You either want sustainability or you don’t.” Pharmaceutical clients operating under ESG mandates are increasingly choosing recyclable solutions that do not compromise thermal reliability.
“It is an exact science,” Griffin says.
During extreme heat events — increasingly common across large regions of the U.S. — the margin for error narrows. “Rarely does an event happen and everything’s 65 degrees and sunshine,” Griffin notes. “Usually extreme heat is involved. If you don’t have something engineered and strictly built to keep things cold during that kind of heat, it’s going to be compromised.” Cold chain failure rarely looks dramatic. It looks ordinary.
Looking ahead, Griffin anticipates packaging that integrates temperature-indicating technology without moving into high-cost active refrigeration systems. “I think eventually packaging will be developed that’ll just tell you that,” he says. Beyond the Box Coldkeepers does not build skyscrapers or lay fiber networks. Its work happens in distribution centers, on loading docks, in staging yards, and on front porches in the middle of summer.
Cold Chain Protection, Engineered.
Patented thermal construction
Validated 2°C–8°C performance
Expanding insulated mailers
Most of the time, no one thinks about it.
The package arrives. The seal is intact. The medication feels cool. The system appears seamless. That is the point. When temperature control works, it disappears into the background. It becomes part of the trust built into the supply chain. But when it fails — during prolonged heat, infrastructure strain, or disaster response — the impact is not always immediate. It appears later, in inventory that cannot be used or medication that cannot be relied on.
Recyclable paper-based options
Made in the USA
Thermal Insulated Handle Bags
In resilience planning, cold chain packaging is often categorized as logistics. In practice, it is embedded risk control. inch and three quarters of EPS. They cost the same, they perform the same. You either want sustainability or you don’t.” “An inch of our paper insulation will outperform an
The difference between 2°C and 8°C may look minor on paper.
In the field, it determines whether a shipment can be used or must be discarded. Whether a hospital can proceed with treatment or wait for a replacement. Whether response efforts move forward or stall.
Gel Packs
Coldkeepers works in that space — where temperature control has to hold.
In disaster response, the smallest variables often determine whether a system continues to function.
That is not a detail. It is a requirement.
When temperature control becomes mission-critical, precision matters.
coldkeepers.com
MADE IN AMERICA
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